Metabolic Interaction Between Schwann Cells and Axons Under Physiological and Disease Conditions.
PNS
Schwann cell
axon
energy metabolism
ketogenic diet
peripheral neuropathy
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
02
2020
accepted:
04
05
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
18
6
2020
Statut:
epublish
Résumé
Recent research into axon-glial interactions in the nervous system has made a compelling case that glial cells have a relevant role in the metabolic support of axons, and that, in the case of myelinating cells, this role is independent of myelination itself. In this mini-review article, we summarize some of those observations and focus on Schwann cells (SC), drawing parallels between glia of the central and peripheral nervous systems (PNS), pointing out limitations in current knowledge, and discussing its potential clinical relevance. First, we introduce SC, their development and main roles, and follow with an evolutionary perspective of glial metabolic function. Then we provide evidence of the myelin-independent aspects of axonal support and their coupling to neuronal metabolism. Finally, we address the opportunity to use SC-axon metabolic interactions as therapeutic targets to treat peripheral neuropathies.
Identifiants
pubmed: 32547370
doi: 10.3389/fncel.2020.00148
pmc: PMC7274022
doi:
Types de publication
Journal Article
Langues
eng
Pagination
148Informations de copyright
Copyright © 2020 Bouçanova and Chrast.
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