Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes.
calcium dependence
cytotoxic T lymphocytes
cytotoxic granules
granule fusion
granule trafficking
immune synapse
synaptotagmin
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
03
2020
accepted:
05
05
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
17
4
2021
Statut:
epublish
Résumé
Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in lymphocytes and mice lacking Syt7 have reduced ability to clear infections. However, fusion of CG persists in the absence of Syt7. To clarify the role of Syt7 in CTL function, we have examined the fusion of cytotoxic granules of CD8
Identifiants
pubmed: 32547563
doi: 10.3389/fimmu.2020.01080
pmc: PMC7273742
doi:
Substances chimiques
Syt7 protein, mouse
0
Synaptotagmins
134193-27-4
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1080Informations de copyright
Copyright © 2020 Sleiman, Stevens, Chitirala and Rettig.
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