A Novel Unidirectional Porous β-tricalcium Phosphate Grafting Impregnated with Bone Marrow Blood Collected from Unfractured Vertebral Bodies for Non-union of Osteoporotic Vertebral Fracture: A Preliminary Case Report.

For the treatment of non-union of osteoporotic vertebral fractures with severe instability, we developed an artificial bone grafting technique using a novel unidirectional β-tricalcium phosphate (Affinos®, Kuraray, Co., Ltd., Tokyo, Japan) impregnated with bone marrow blood collected from normal unfractured vertebral bodies to promote the formation of new bone. An 87-year-old woman exhibited gait disturbance due to delayed leg paralysis secondary to non-union of an osteoporotic fracture of the T12 vertebral body. Artificial bone grafting was performed with 7.5 g of the β-tricalcium phosphate granules impregnated with 12 mL of bone marrow blood collected from normal vertebral bodies, where pedicle screws would be inserted. Three months after surgery, the cortex of the anterior vertebral wall was regenerated, and bone union was completed. For up to 1 year after surgery, absorption of the artificial bone and formation of new bone had been observed. Artificial bone grafting technique using the novel unidirectional β-tricalcium phosphate impregnated with bone marrow blood collected from normal unfractured vertebral bodies is a useful and innovative surgical technique for the treatment of non-union of osteoporotic vertebral fractures with severe vertebral instability.

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