Excess serum uric acid is associated with metabolic syndrome in obese adolescent patients.
Adolescents
Hyperuricemia
Inflammation
Metabolic syndrome
Obesity
Journal
Journal of diabetes and metabolic disorders
ISSN: 2251-6581
Titre abrégé: J Diabetes Metab Disord
Pays: Switzerland
ID NLM: 101590741
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
15
07
2019
accepted:
06
02
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
18
6
2020
Statut:
epublish
Résumé
Obesity is a significant cause of morbidity in adolescents. Excess serum uric acid (SUA) has been associated with metabolic syndrome (MS) among adults. We evaluated the relationship among SUA and markers of insulin resistance (IR) and low-grade inflammation in obese adolescents with and without MS. The study was a retrospective chart review of obese patients seen in the LeBonheur Endocrine clinic seen in clinic between September 2016 and December 2017. MS was defined as according to the International Diabetes Federation. Body mass index standard deviation score (BMI SDS), systolic blood pressure (SBP), diastolic blood pressure (DBP), body composition, fasting lipids, glucose, high sensitivity c-reactive protein (hs-CRP), serum uric acid (SUA), HbA1c, alanine transferase (ALT), aspartate transferase (AST), insulin and homeostatic model assessment for insulin resistance (HOMA-IR) were extracted from the charts of the 100 obese adolescents (57% female). Hyperuricemia (SUA >357 umol/L) was present in 41.8% of entire cohort without significant ethnic/racial and/or gender differences. Adolescents with HUA had higher FM, SBP, HbA1c, insulin and HOMA-IR ( In our study, those with hyperuricemia (HUA) showed elevated markers of metabolic syndrome including BP, serum glucoses, IR and triglycerides. In our cohort, SUA appears to correlate with MS comorbidities.
Identifiants
pubmed: 32548073
doi: 10.1007/s40200-020-00507-2
pii: 507
pmc: PMC7270295
doi:
Types de publication
Journal Article
Langues
eng
Pagination
535-543Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Conflict of interestThe authors have no conflict of interest to disclose.
Références
J Hum Hypertens. 2014 Oct;28(10):579-86
pubmed: 24785975
Metab Syndr Relat Disord. 2016 Apr;14(3):167-74
pubmed: 26824485
Pediatr Diabetes. 2015 Sep;16(6):441-7
pubmed: 25131560
JAMA. 2016 Jun 7;315(21):2284-91
pubmed: 27272580
Hypertension. 2012 Apr;59(4):811-7
pubmed: 22353609
Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1360-4
pubmed: 25063537
Atherosclerosis. 2011 Apr;215(2):475-80
pubmed: 21300354
Diabetes Metab. 2005 Dec;31(6):534-41
pubmed: 16357801
Arch Physiol Biochem. 2014 Jul;120(3):119-22
pubmed: 24914748
Arthritis Care Res (Hoboken). 2013 Jan;65(1):133-40
pubmed: 22933424
Appl Physiol Nutr Metab. 2013 Jan;38(1):27-32
pubmed: 23368825
Gac Med Mex. 2017;153(Supl. 2):S42-S50
pubmed: 29099118
Endocrinol Nutr. 2012 Nov;59(9):533-8
pubmed: 23089370
J Pediatr (Rio J). 2007 Sep-Oct;83(5):477-80
pubmed: 17768492
Diabetes Metab Syndr. 2013 Apr-Jun;7(2):72-7
pubmed: 23680244
Einstein (Sao Paulo). 2015 Apr-Jun;13(2):202-8
pubmed: 26018145
Circulation. 2007 May 15;115(19):2526-32
pubmed: 17470699
Curr Diabetes Rev. 2014 Mar;10(2):113-7
pubmed: 24588601
Curr Opin Rheumatol. 2013 Mar;25(2):210-6
pubmed: 23370374
Biomarkers. 2015;20(4):225-31
pubmed: 26301880
Clin Chem. 1972 Jun;18(6):499-502
pubmed: 4337382
Dis Model Mech. 2009 May-Jun;2(5-6):231-7
pubmed: 19407331
Obesity (Silver Spring). 2016 Jun;24(6):1389-96
pubmed: 27145150
Acta Paediatr. 2012 May;101(5):497-500
pubmed: 22211844
Indian J Pediatr. 2018 Jul;85(7):535-545
pubmed: 29218646
Fertil Steril. 2007 Nov;88(5):1389-95
pubmed: 17462641
Curr Med Res Opin. 2015;31 Suppl 2:9-14
pubmed: 26414731
Ann Clin Biochem. 2013 Sep;50(Pt 5):457-64
pubmed: 23880621
Arthritis Rheum. 2011 Oct;63(10):3136-41
pubmed: 21800283
J Pediatr (Rio J). 2017 Sep - Oct;93(5):538-543
pubmed: 28450054
Rheumatology (Oxford). 2014 Nov;53(11):2053-62
pubmed: 24917566
Metabolism. 2016 Apr;65(4):432-40
pubmed: 26975535
Matern Child Health J. 2016 Sep;20(9):1933-9
pubmed: 27112556
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Diabetes. 2011 Apr;60(4):1258-69
pubmed: 21346177
Endocr Pract. 2012 May-Jun;18(3):356-62
pubmed: 22138077
Physiol Meas. 2008 Jun;29(6):S517-24
pubmed: 18544819
PLoS One. 2014 Dec 01;9(12):e114259
pubmed: 25437867
Pediatr Diabetes. 2007 Oct;8(5):299-306
pubmed: 17850473
Obesity (Silver Spring). 2009 Dec;17(12):2245-50
pubmed: 19373222
Ann Intern Med. 2010 Jun 15;152(12):770-7
pubmed: 20547905
PLoS One. 2014 May 14;9(5):e97646
pubmed: 24827988
J Pediatr. 2008 Feb;152(2):201-6
pubmed: 18206689
Am J Epidemiol. 2012 Jul 15;176(2):108-16
pubmed: 22753829
Am J Hum Biol. 2018 Jan;30(1):
pubmed: 28987018