First Total Synthesis and in Vitro Cytotoxicities of Flavesines G and J.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
02 Jun 2020
02 Jun 2020
Historique:
received:
12
04
2020
accepted:
08
05
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
18
6
2020
Statut:
epublish
Résumé
The first total synthesis of flavesines G and J, natural products exhibiting antiviral activity against hepatitis B virus, is described. A robust, protecting-group-free route starting from commercially available natural product 9-azajulolidine allowed us to obtain the title compounds in a four- and five-step sequence accordingly. Flavesines G and J exhibit micromolar cytotoxicity in A549, MCF-7, HepG2, PANC-1, and HL-60 cancer cell lines.
Identifiants
pubmed: 32548440
doi: 10.1021/acsomega.0c01672
pmc: PMC7271405
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12568-12572Informations de copyright
Copyright © 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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