Nanocarriers as Potential Drug Delivery Candidates for Overcoming the Blood-Brain Barrier: Challenges and Possibilities.

Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
09 Jun 2020
Historique:
received: 07 04 2020
accepted: 18 05 2020
entrez: 18 6 2020
pubmed: 18 6 2020
medline: 18 6 2020
Statut: epublish

Résumé

The design of a drug that successfully overcomes the constraints imposed by the blood-brain barrier (BBB, which acts as a gatekeeper to the entry of substances into the brain) requires an understanding of the biological firewall. It is also of utmost importance to understand the physicochemical properties of the said drug and how it engages the BBB to avoid undesired side effects. Since fewer than 5% of the tested molecules can pass through the BBB, drug development pertaining to brain-related disorders takes inordinately long to develop. Furthermore, in most cases it is also unsuccessful for allied reasons. Several drug delivery systems (DDSs) have shown excellent potential in drug delivery across the BBB while demonstrating minimal side effects. This mini-review summarizes key features of the BBB, recapitulates recent advances in our understanding of the BBB, and highlights existing strategies for the delivery of drug to the brain parenchyma.

Identifiants

DOI: 10.1021/acsomega.0c01592 PMID: 32548442 PMC: PMC7288355
pubmed: 32548442
doi: 10.1021/acsomega.0c01592
pmc: PMC7288355
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

12583-12595

Subventions

Organisme : NIGMS NIH HHS
ID : RL5 GM118969
Pays : United States
Organisme : NIGMS NIH HHS
ID : TL4 GM118971
Pays : United States
Organisme : NIGMS NIH HHS
ID : UL1 GM118970
Pays : United States

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Jyoti Ahlawat (J)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Gileydis Guillama Barroso (G)

Department of Chemistry, The University of Havana, Havana, Cuba.

Shima Masoudi Asil (S)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Melinda Alvarado (M)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Isabela Armendariz (I)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Jose Bernal (J)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Ximena Carabaza (X)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Stephanie Chavez (S)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Paulina Cruz (P)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Vassti Escalante (V)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Savana Estorga (S)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Daniel Fernandez (D)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Carolina Lozano (C)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Martin Marrufo (M)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Nabeel Ahmad (N)

School of Biotechnology, IFTM University, Moradabad, India.

Sergio Negrete (S)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Karyme Olvera (K)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Ximena Parada (X)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Brianna Portillo (B)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Andrea Ramirez (A)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Raul Ramos (R)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Veronica Rodriguez (V)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Paola Rojas (P)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Jessica Romero (J)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

David Suarez (D)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Graciela Urueta (G)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Stephanie Viel (S)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Mahesh Narayan (M)

Department of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.

Classifications MeSH