IGF-1 and cardiometabolic diseases: a Mendelian randomisation study.
IGF-1
Insulin-like growth factor
Mendelian randomisation
Type 2 diabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
22
02
2020
accepted:
21
04
2020
pubmed:
18
6
2020
medline:
7
10
2021
entrez:
18
6
2020
Statut:
ppublish
Résumé
Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. We employed Mendelian randomisation to explore the associations between genetically predicted serum IGF-1 levels and cardiometabolic diseases. Serum IGF-1 levels were predicted using 416 SNPs associated with IGF-1 levels among 358,072 individuals in UK Biobank. Genetic association estimates for the outcomes were obtained from consortia of type 2 diabetes (74,124 cases, 824,006 controls), coronary artery disease (60,801 cases, 123,504 controls), heart failure (47,309 cases, 930,014 controls), atrial fibrillation (65,446 cases, 522,744 controls), and ischaemic stroke (60,341 cases, 454,450 controls). Genetic predisposition to elevated serum IGF-1 levels was associated with higher risk of type 2 diabetes and coronary artery disease. The OR (95% CI) per SD increment in IGF-1 level was 1.14 (1.05, 1.24) for type 2 diabetes and 1.09 (1.02, 1.16) for coronary artery disease. The association between IGF-1 and coronary artery disease was attenuated after adjustment for type 2 diabetes (OR 1.06 [95% CI 1.00, 1.13]), suggesting that the association may be partly mediated via type 2 diabetes. There was limited evidence of associations between IGF-1 levels and heart failure, atrial fibrillation and ischaemic stroke. This study found evidence that increased IGF-1 levels may be causally associated with higher risk of type 2 diabetes. Graphical abstract.
Identifiants
pubmed: 32548700
doi: 10.1007/s00125-020-05190-9
pii: 10.1007/s00125-020-05190-9
pmc: PMC7406523
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1775-1782Subventions
Organisme : Wellcome Trust
ID : 204623/Z/16/Z
Pays : United Kingdom
Organisme : Vetenskapsrådet
ID : 2019-00977
Pays : International
Organisme : Forskningsrådet om Hälsa, Arbetsliv och Välfärd
ID : 2018-00123
Pays : International
Organisme : Hjärt-Lungfonden
ID : 20190247
Pays : International
Organisme : Medical Research Council
ID : MC_UU_00002/7
Pays : United Kingdom
Références
Nat Genet. 2012 Sep;44(9):991-1005
pubmed: 22885924
J Endocrinol Invest. 2012 Dec;35(11):1021-9
pubmed: 23143695
Br J Nutr. 2019 Apr;121(8):938-944
pubmed: 30898176
Elife. 2018 May 30;7:
pubmed: 29846171
Epidemiology. 2017 Jan;28(1):30-42
pubmed: 27749700
J Clin Endocrinol Metab. 2007 Apr;92(4):1319-25
pubmed: 17264182
Int J Epidemiol. 2017 Dec 1;46(6):1734-1739
pubmed: 28398548
Curr Diab Rep. 2017 Feb;17(2):8
pubmed: 28150161
J Clin Endocrinol Metab. 2005 Nov;90(11):5937-41
pubmed: 16131586
Am J Clin Nutr. 2005 May;81(5):1163-7
pubmed: 15883443
Atherosclerosis. 2011 Oct;218(2):464-9
pubmed: 21708381
Circulation. 2002 Aug 20;106(8):939-44
pubmed: 12186797
Nat Genet. 2014 Nov;46(11):1173-86
pubmed: 25282103
Nature. 2015 Feb 12;518(7538):187-196
pubmed: 25673412
Diabetes. 2017 Nov;66(11):2888-2902
pubmed: 28566273
Int J Mol Epidemiol Genet. 2011 Aug 30;2(3):261-85
pubmed: 21915365
Diabetes Care. 2012 Apr;35(4):768-73
pubmed: 22374641
Atherosclerosis. 2008 Nov;201(1):198-204
pubmed: 18295769
Clin Nutr. 2019 Feb;38(1):159-164
pubmed: 29395372
Nat Genet. 2018 Sep;50(9):1225-1233
pubmed: 29892015
Nat Genet. 2013 Nov;45(11):1274-1283
pubmed: 24097068
Nat Genet. 2010 Feb;42(2):105-16
pubmed: 20081858
Am J Epidemiol. 2015 Feb 15;181(4):251-60
pubmed: 25632051
Diabetes. 2012 Sep;61(9):2248-54
pubmed: 22554827
Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):277-82
pubmed: 9484994
Stroke. 2017 Jul;48(7):1760-1765
pubmed: 28596451
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Lancet. 2002 May 18;359(9319):1740-5
pubmed: 12049864
J Clin Endocrinol Metab. 2014 Nov;99(11):E2308-16
pubmed: 25057875
Eur J Endocrinol. 2008 Feb;158(2):153-61
pubmed: 18230821
Nat Genet. 2017 Jun;49(6):946-952
pubmed: 28416818
J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):1025-32
pubmed: 24368776
Nat Commun. 2020 Jan 9;11(1):163
pubmed: 31919418
Clin Chem. 2008 Oct;54(10):1682-8
pubmed: 18703768
Eur J Endocrinol. 2010 Aug;163(2):233-42
pubmed: 20508082
Nat Genet. 2015 Oct;47(10):1121-1130
pubmed: 26343387
Nat Genet. 2018 Nov;50(11):1505-1513
pubmed: 30297969
Nutrients. 2019 Nov 15;11(11):
pubmed: 31731672
Ann Intern Med. 2003 Oct 21;139(8):642-8
pubmed: 14568852
Int J Food Sci Nutr. 2009;60 Suppl 7:330-40
pubmed: 19746296
Am J Epidemiol. 2016 Mar 15;183(6):553-60
pubmed: 26880678
Nat Genet. 2018 Apr;50(4):524-537
pubmed: 29531354
Clin Nutr. 2020 Jun;39(6):1705-1716
pubmed: 31431306
Nature. 2015 Feb 12;518(7538):197-206
pubmed: 25673413
Calcif Tissue Int. 2019 Oct;105(4):383-391
pubmed: 31338563
PLoS Med. 2016 Nov 29;13(11):e1002179
pubmed: 27898682