Genome-wide association study identifies variants associated with hair length in Brangus cattle.
biotin
prolactin
thermotolerance
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
accepted:
20
05
2020
pubmed:
18
6
2020
medline:
19
12
2020
entrez:
18
6
2020
Statut:
ppublish
Résumé
Thermal stress limits beef cattle production and a shorter hair coat is a key thermoregulative adaptation that allows cattle to lose heat more efficiently. The objective of this study was to identify genetic variants associated with the length of the undercoat and topcoat of cattle utilizing 1456 Brangus heifers genotyped with the Bovine GGP F250 array. Seven SNPs in the PCCA gene were significantly associated with undercoat length. PCCA belongs to the biotin transport and metabolism pathway. Biotin deficiency has been reported to cause hair loss. Four SNPs in an 110 kb including a missense mutation in the PRLR gene were significantly associated with topcoat length. Whereas the association of this polymorphism with hair length is novel, the SLICK mutation in PRLR has previously been demonstrated to significantly impact hair length in cattle. These newly detected genetic variants may contribute to a shorter hair coat and more thermotolerant animals.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
811-814Subventions
Organisme : USDA-NIFA
ID : 2017-67007-26143
Organisme : The International Brangus Breeders Association
Organisme : Seminole Tribe of Florida
Organisme : UF ANS Hatch Project
Informations de copyright
© 2020 Stichting International Foundation for Animal Genetics.
Références
Amundson J.L., Mader T.L., Rasby R.J. & Hu Q.S. (2006) Environmental effects on pregnancy rate in beef cattle. Journal of Animal Science 84, 3415-20.
Boccaletti V., Zendri E., Giordano G., Gnetti L. & De Panfilis G. (2007) Familial uncombable hair syndrome: ultrastructural hair study and response to biotin. Pediatric Dermatology 24, 14-6.
Bryant K.L., Kornegay E.T., Knight J.W., Webb K.E. & Notter D.R. (1985) Supplemental biotin for swine. II. Influence of supplementation to corn- and wheat-based diets on reproductive performance and various biochemical criteria of sows during four parities. Journal of Animal Science 60, 145-53.
Burrow H.M. (2012) Importance of adaptation and genotype × environment interactions in tropical beef breeding systems. Animal 6, 729-40.
Campeau E., Desviat L.R., Leclerc D., Wu X., Pérez B., Ugarte M. & Gravel R.A. (2001) Structure of the PCCA gene and distribution of mutations causing propionic acidemia. Molecular Genetics and Metabolism 74, 238-47.
Craven A.J., Ormandy C.J., Robertson F.G., Wilkins R.J., Kelly P.A., Nixon A.J., Pearson A.J. & Craven T. (2001) Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice. Endocrinology 142, 2533-9.
Dakshinamurti K. (1988) Regulation of biotin enzymes. Annual Review of Nutrition 8, 211-33.
Hamblen H., Hansen P.J., Zolini A.M., Oltenacu P.A. & Mateescu R.G. (2018) Thermoregulatory response of Brangus heifers to naturally occurring heat exposure on pasture. Journal of Animal Science 96, 3131-7.
Hansen P.J. (2004) Physiological and cellular adaptations of zebu cattle to thermal stress. Animal Reproduction Science 82-83, 349-60.
Hernandez-Cordero A.I., Castro M. A. S., Algandar R. Z., Nevarez P. L., Rincon G., Medrano J. F., Speidel S. E., Enns R. M. & Thomas M. G. (2017) Genotypes within the prolactin and growth hormone insulin-like growth factor-I pathways associated with milk production in heat stressed holstein cattle: genotypes and milk yield in heat stressed holstein cows. Genetics and Molecular Research 16(4), https://doi.org/10.4238/gmr16039821
Horseman ND, Gregerson KA (2013) Prolactin actions. Journal of Molecular Endocrinology 52, R95-106. https://doi.org/10.1530/JME-13-0220
Littlejohn M.D., Henty K.M., Tiplady K. et al. (2014) Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle. Nature Communications 5, 1-8.
Olson T.A., Lucena C., Chase C.C. Jr & Hammond A.C. (2003) Evidence of a major gene influencing hair length and heat tolerance in Bos taurus cattle1,2,3. Journal of Animal Science 81, 80-90.
Porto-Neto L.R., Bickhart D.M., Landaeta-Hernandez A.J. et al. (2018) Convergent evolution of slick coat in cattle through truncation mutations in the prolactin receptor. Frontiers in Genetics 9, 1-8.
Purcell S., Neale B., Todd-Brown K. et al. (2007) PLINK: A tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics 81, 559-75.
Rauch H. (1952) The effects of biotin deficiency on hair development and pigmentation. Physiological Zoology 25, 145-9.
Renaudeau D., Collin A., Yahav S., de Basilio V., Gourdine J.L. & Collier R.J. (2012) Adaptation to hot climate and strategies to alleviate heat stress in livestock production. Animal 6, 707-28.
Sarlo Davila K.M., Hamblen H., Hansen P.J., Dikmen S., Oltenacu P.A. & Mateescu R.G. (2019) Genetic parameters for hair characteristics and core body temperature in a multibreed Brahman-Angus herd1. Journal of Animal Science 97, 3246-52.
Schindelin J., Arganda-Carreras I., Frise E. et al. (2012) Fiji: an open-source platform for biological-image analysis. Nature Methods 9, 676-82.
St-Pierre N.R., Cobanov B. & Schnitkey G. (2003) Economic losses from heat stress by US livestock industries. Journal of Dairy Science 86, E52-77.
Wolf B. & Raetz H. (1983) The measurement of propionyl-CoA carboxylase and pyruvate carboxylase activity in hair roots: its use in the diagnosis of inherited biotin-dependent enzyme deficiencies. Clinica Chimica Acta 130, 25-30.
Zhou X. & Stephens M. (2012) Genome-wide efficient mixed-model analysis for association studies. Nature Genetics 44, 821-4.