A critical role for CARD9 in pneumocystis pneumonia host defence.
Animals
CARD Signaling Adaptor Proteins
/ genetics
Cell Differentiation
Colony Count, Microbial
Cytokines
/ metabolism
Immunocompromised Host
Lectins, C-Type
/ genetics
Lung
/ enzymology
Macrophages, Alveolar
/ cytology
Membrane Proteins
/ genetics
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases
/ metabolism
Peroxidase
/ metabolism
Pneumocystis
/ growth & development
Pneumocystis carinii
/ growth & development
Pneumonia, Pneumocystis
/ immunology
Rats
T-Lymphocytes, Helper-Inducer
/ immunology
Tumor Necrosis Factor-alpha
/ metabolism
CARD9
Pneumocystis
host defence
inflammation
macrophage
Journal
Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
03
02
2020
revised:
15
05
2020
accepted:
09
06
2020
pubmed:
18
6
2020
medline:
31
7
2021
entrez:
18
6
2020
Statut:
ppublish
Résumé
Caspase recruitment domains-containing protein 9 (CARD9) is an adaptor molecule critical for key signalling pathways initiated through C-type lectin receptors (CLRs). Previous studies demonstrated that Pneumocystis organisms are recognised through a variety of CLRs. However, the role of the downstream CARD9 adaptor signalling protein in host defence against Pneumocystis infection remains to be elucidated. Herein, we analysed the role of CARD9 in host defence against Pneumocystis both in CD4-depleted CARD9
Identifiants
pubmed: 32548948
doi: 10.1111/cmi.13235
pmc: PMC7755114
mid: NIHMS1603920
doi:
Substances chimiques
CARD Signaling Adaptor Proteins
0
Card9 protein, mouse
0
Clecsf8 protein, mouse
0
Cytokines
0
Lectins, C-Type
0
Membrane Proteins
0
Tumor Necrosis Factor-alpha
0
dectin 1
0
Peroxidase
EC 1.11.1.7
Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13235Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL062150
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Trends Immunol. 2013 Jun;34(6):243-50
pubmed: 23523010
Infect Immun. 2014 Apr;82(4):1606-15
pubmed: 24470469
Nat Immunol. 2009 Feb;10(2):203-13
pubmed: 19122653
Blood. 2013 Mar 28;121(13):2385-92
pubmed: 23335372
Clin Infect Dis. 2014 Jul 1;59(1):81-4
pubmed: 24704721
Nature. 2006 Aug 10;442(7103):651-6
pubmed: 16862125
Am J Respir Cell Mol Biol. 2013 Oct;49(4):503-10
pubmed: 23672262
JCI Insight. 2016 Oct 20;1(17):e89890
pubmed: 27777981
J Clin Immunol. 2015 Jul;35(5):486-90
pubmed: 26044242
Interdiscip Perspect Infect Dis. 2011;2011:918038
pubmed: 21904545
Trends Immunol. 2009 May;30(5):234-42
pubmed: 19359218
Nat Immunol. 2007 Jan;8(1):39-46
pubmed: 17159982
J Clin Invest. 1990 May;85(5):1686-93
pubmed: 2139668
J Allergy Clin Immunol. 2014 Mar;133(3):905-8.e3
pubmed: 24231284
Nat Rev Immunol. 2006 Jul;6(7):532-40
pubmed: 16799472
JCI Insight. 2018 Jun 21;3(12):
pubmed: 29925696
J Exp Med. 2010 Dec 20;207(13):2907-19
pubmed: 21149550
Nat Immunol. 2005 Dec;6(12):1198-205
pubmed: 16369559
Immunol Lett. 2009 Dec 2;127(1):55-9
pubmed: 19733591
Front Cell Infect Microbiol. 2016 Apr 05;6:39
pubmed: 27092298
Mycopathologia. 2015 Jun;179(5-6):347-57
pubmed: 25790941
Cancer. 2005 Nov 1;104(9):1885-93
pubmed: 16177990
Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L252-60
pubmed: 19915161
N Engl J Med. 2013 Oct 31;369(18):1704-1714
pubmed: 24131138
Pediatr Infect Dis J. 2016 Apr;35(4):428-31
pubmed: 26658378
Ann N Y Acad Sci. 2008 Nov;1143:35-44
pubmed: 19076343
J Clin Invest. 1998 Oct 1;102(7):1332-44
pubmed: 9769325
Eur J Immunol. 2011 Feb;41(2):276-81
pubmed: 21267996
JAMA Dermatol. 2015 Feb;151(2):192-4
pubmed: 25372963
Lancet Infect Dis. 2017 Nov;17(11):e334-e343
pubmed: 28774701
Am J Respir Cell Mol Biol. 2000 Jun;22(6):722-31
pubmed: 10837370
Nat Immunol. 2007 Feb;8(2):198-205
pubmed: 17187069
Nat Rev Microbiol. 2007 Apr;5(4):298-308
pubmed: 17363968
PLoS Pathog. 2018 Feb 22;14(2):e1006807
pubmed: 29470553
J Immunol. 2009 Jan 15;182(2):1146-54
pubmed: 19124758
Br J Dermatol. 2016 Jan;174(1):176-9
pubmed: 26440558
J Immunol. 2017 May 1;198(9):3515-3525
pubmed: 28298521
PLoS Pathog. 2015 Jan 26;11(1):e1004589
pubmed: 25621893
Infect Immun. 2020 Jan 22;88(2):
pubmed: 31611280
J Infect Dis. 2015 Apr 15;211(8):1241-50
pubmed: 25057046
Pediatr Infect Dis J. 2015 Sep;34(9):999-1002
pubmed: 25933095
Infect Immun. 2015 Feb;83(2):671-81
pubmed: 25422263
N Engl J Med. 2009 Oct 29;361(18):1727-35
pubmed: 19864672
Nat Immunol. 2002 Sep;3(9):830-5
pubmed: 12154356
J Pediatr Surg. 2001 Feb;36(2):334-7
pubmed: 11172428
PLoS Pathog. 2015 Dec 17;11(12):e1005293
pubmed: 26679537
Immunology. 2008 Nov;125(3):281-8
pubmed: 19128361
Immunity. 2010 May 28;32(5):681-91
pubmed: 20493731
J Biol Chem. 2010 Aug 20;285(34):25969-77
pubmed: 20538615
Am J Respir Cell Mol Biol. 2018 Feb;58(2):232-240
pubmed: 28886250
Annu Rev Immunol. 2002;20:55-72
pubmed: 11861597
J Clin Invest. 1997 May 1;99(9):2110-7
pubmed: 9151783
Infect Immun. 2016 Aug 29;84(11):3195-3205
pubmed: 27572330
Infect Immun. 1995 Mar;63(3):779-84
pubmed: 7868247
J Allergy Clin Immunol. 2015 Jun;135(6):1558-68.e2
pubmed: 25702837
J Exp Med. 2010 Apr 12;207(4):777-92
pubmed: 20351059
Nat Immunol. 2012 Sep;13(9):817-22
pubmed: 22910394
N Engl J Med. 2004 Jun 10;350(24):2487-98
pubmed: 15190141
Immunity. 2012 Jan 27;36(1):32-42
pubmed: 22265677