Neuroendocrine Targeting of Tissue Plasminogen Activator (t-PA).
Tissue plasminogen activator
chromogranin A
regulated secretion
Journal
Journal of neurological disorders & stroke
Titre abrégé: J Neurol Disord Stroke
Pays: United States
ID NLM: 101622799
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
18
6
2020
Statut:
ppublish
Résumé
t-PA has a widespread neuroendocrine distribution including prominent expression in chromaffin cells of the sympathoadrenal system. Chromaffin cell t-PA is sorted into catecholamine storage vesicles and co-released with catecholamines in response to sympathoadrenal activation, suggesting that catecholamine storage vesicles may serve as a reservoir for the rapid release of t-PA. Chromogranin A (CgA), a major core protein in secretory vesicles throughout the neuroendocrine system, may play a crucial role in targeting proteins into the regulated secretory pathway, by forming aggregated "granin" complexes to which other proteins destined for the regulated secretory vesicle bind and become separated from constitutively secreted proteins in the trans-Golgi network (TGN). Formation of such complexes is facilitated by conditions of the TGN (low pH, high Ca
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL050398
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL081046
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL045934
Pays : United States
Organisme : BLRD VA
ID : I01 BX002026
Pays : United States
Organisme : BLRD VA
ID : I01 BX003933
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149511
Pays : United States
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