Novel Polymeric Micelles-Coated Magnetic Nanoparticles for In Vivo Bioimaging of Liver: Toxicological Profile and Contrast Enhancement.
MRI
contrast agents
magnetite nanoparticles
polymeric micelles
toxicity
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
15 Jun 2020
15 Jun 2020
Historique:
received:
25
05
2020
revised:
10
06
2020
accepted:
11
06
2020
entrez:
19
6
2020
pubmed:
19
6
2020
medline:
19
6
2020
Statut:
epublish
Résumé
Magnetic nanoparticles are intensively studied for magnetic resonance imaging (MRI) as contrast agents but yet there remained some gaps regarding their toxicity potential and clinical implications of their biodistribution in organs. This study presents the effects induced by magnetite nanoparticles encapsulated in polymeric micelles (MNP-DSPE-PEG) on biochemical markers, metabolic functions, and MRI signal in CD1 mice liver. Three groups of animals, one control and the other ones injected with a suspension of five, respectively, 15 mg Fe/kg bw nanoparticles, were monitored up to 14 days. The results indicated the presence of MNP-DSPE-PEG in the liver in the first two days of the experiment. The most significant biochemical changes also occurred in the first 3 days after exposure when the most severe histological changes were observed. The change of the MRI signal intensity on the T2-weighted images and increased transverse relaxation rates R
Identifiants
pubmed: 32549296
pii: ma13122722
doi: 10.3390/ma13122722
pmc: PMC7345181
pii:
doi:
Types de publication
Journal Article
Langues
eng
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