Main gut bacterial composition differs between patients with type 1 and type 2 diabetes and non-diabetic adults.

Diabetes mellitus Gut dysbiosis Gut microbiota

Journal

Journal of diabetes and metabolic disorders
ISSN: 2251-6581
Titre abrégé: J Diabetes Metab Disord
Pays: Switzerland
ID NLM: 101590741

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 07 12 2019
accepted: 30 01 2020
entrez: 19 6 2020
pubmed: 19 6 2020
medline: 19 6 2020
Statut: epublish

Résumé

Regarding the role of gut microbial dysbiosis in hyperglycemia, we aimed to compare the main gut bacterial composition among type 1 and type 2 diabetic patients and healthy non-diabetic adults. A total of 110 adult subjects (49 patients diagnosed with type 2 diabetes, 21 patients diagnosed with type 1 diabetes and 40 healthy persons) were included in this case-control study. The intestinal microbiota composition was investigated by quantitative real-time polymerase chain reaction (qPCR) method targeting bacterial 16S rRNA gene. Comparison between three groups was done using one-way analysis of variance. The participants' mean age in the type 1 diabetes, type 2 diabetes and control groups was 35.4, 57.2 and 38.0 years, respectively. Higher level of Gut microbial alterations have been observed among patients suffering from type 1 and type 2 diabetes mellitus and healthy control adults. Butyrate producing genera including

Sections du résumé

BACKGROUND BACKGROUND
Regarding the role of gut microbial dysbiosis in hyperglycemia, we aimed to compare the main gut bacterial composition among type 1 and type 2 diabetic patients and healthy non-diabetic adults.
METHODS METHODS
A total of 110 adult subjects (49 patients diagnosed with type 2 diabetes, 21 patients diagnosed with type 1 diabetes and 40 healthy persons) were included in this case-control study. The intestinal microbiota composition was investigated by quantitative real-time polymerase chain reaction (qPCR) method targeting bacterial 16S rRNA gene. Comparison between three groups was done using one-way analysis of variance.
RESULTS RESULTS
The participants' mean age in the type 1 diabetes, type 2 diabetes and control groups was 35.4, 57.2 and 38.0 years, respectively. Higher level of
CONCLUSIONS CONCLUSIONS
Gut microbial alterations have been observed among patients suffering from type 1 and type 2 diabetes mellitus and healthy control adults. Butyrate producing genera including

Identifiants

DOI: 10.1007/s40200-020-00502-7 PMID: 32550175 PMC: PMC7270240
pubmed: 32550175
doi: 10.1007/s40200-020-00502-7
pii: 502
pmc: PMC7270240
doi:

Types de publication

Journal Article

Langues

eng

Pagination

265-271

Informations de copyright

© Springer Nature Switzerland AG 2020.

Déclaration de conflit d'intérêts

Conflict of interestsThe authors declare that they have no competing interests.

Références

Sci Rep. 2014 Jan 22;4:3814
pubmed: 24448554
Diabetes Res Clin Pract. 2018 Jul;141:256-263
pubmed: 29733871
Altern Ther Health Med. 2017 Nov;23(6):8-9
pubmed: 28987073
J Diabetes Metab Disord. 2019 Feb 1;18(1):263-265
pubmed: 31275897
PLoS One. 2013 Aug 27;8(8):e71108
pubmed: 24013136
Nature. 2015 Dec 10;528(7581):262-266
pubmed: 26633628
Best Pract Res Clin Gastroenterol. 2013 Feb;27(1):73-83
pubmed: 23768554
PLoS One. 2011;6(10):e25792
pubmed: 22043294
Biochem Biophys Res Commun. 2009 Apr 17;381(4):666-70
pubmed: 19248769
Future Microbiol. 2017 Feb;12:157-170
pubmed: 28139139
Gut. 2014 Sep;63(9):1513-21
pubmed: 24833634
BMC Med. 2013 Feb 21;11:46
pubmed: 23433344
Microbiome. 2015 Sep 03;3:37
pubmed: 26334878
Microbiome. 2016 Apr 26;4:17
pubmed: 27114075
Int J Obes (Lond). 2019 Jan;43(1):149-157
pubmed: 29777234
Nature. 2013 Jun 6;498(7452):99-103
pubmed: 23719380
Diabetes Care. 2018 Nov;41(11):2385-2395
pubmed: 30224347
BMC Genomics. 2018 Dec 14;19(1):931
pubmed: 30547746
Diabetes Res Clin Pract. 2010 Jan;87(1):2-3
pubmed: 19962207
Complement Ther Med. 2019 Feb;42:184-204
pubmed: 30670241
Lipids Health Dis. 2016 Jun 18;15:108
pubmed: 27317359
Front Endocrinol (Lausanne). 2019 Jan 30;10:29
pubmed: 30761090
Sci Rep. 2015 Nov 13;5:16643
pubmed: 26563823
Science. 2012 Jun 8;336(6086):1262-7
pubmed: 22674330
Adv Neonatal Care. 2015 Dec;15(6):386-93
pubmed: 26551793
Microb Pathog. 2018 Mar;116:13-21
pubmed: 29306011
J Appl Microbiol. 2004;97(6):1166-77
pubmed: 15546407
EBioMedicine. 2019 Aug;46:512-521
pubmed: 31257149
Nature. 2012 Oct 4;490(7418):55-60
pubmed: 23023125
Pediatr Int. 2014 Jun;56(3):336-43
pubmed: 24475780
Gut Microbes. 2012 Jul-Aug;3(4):279-88
pubmed: 22572877
FEMS Microbiol Ecol. 2012 Jun;80(3):608-23
pubmed: 22324938
Horm Metab Res. 2016 Jun;48(6):349-58
pubmed: 27203411
Eur J Endocrinol. 2018 Dec 1;:
pubmed: 30540558
Nature. 2011 May 12;473(7346):174-80
pubmed: 21508958
Microb Pathog. 2017 Oct;111:362-369
pubmed: 28912092
Clin Immunol. 2015 Aug;159(2):143-53
pubmed: 26051037
Curr Diabetes Rev. 2019;15(6):480-485
pubmed: 30727901
Appl Environ Microbiol. 2004 Jun;70(6):3575-81
pubmed: 15184159
PLoS One. 2010 Feb 05;5(2):e9085
pubmed: 20140211
Int J Mol Sci. 2014 Mar 07;15(3):4158-88
pubmed: 24608927

Auteurs

Hanieh-Sadat Ejtahed (HS)

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Zahra Hoseini-Tavassol (Z)

Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Shohre Khatami (S)

Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.

Mehrangiz Zangeneh (M)

Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Ava Behrouzi (A)

Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Sara Ahmadi Badi (S)

Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Arfa Moshiri (A)

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Shirin Hasani-Ranjbar (S)

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Ahmad-Reza Soroush (AR)

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Farzam Vaziri (F)

Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Abolfazl Fateh (A)

Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Mostafa Ghanei (M)

Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Saeid Bouzari (S)

Molecular Biology Department, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Shahin Najar-Peerayeh (S)

Bacteriology Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Seyed Davar Siadat (SD)

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.
ORCID: 0000-0002-6892-5603

Bagher Larijani (B)

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Classifications MeSH