Effect of Roflumilast in airways disorders via dual inhibition of phosphodiesterase and Ca

Bronchodilatation Ca++ channel blocker Papaverine Phosphodiesterase inhibitor Roflumilast

Journal

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
ISSN: 1319-0164
Titre abrégé: Saudi Pharm J
Pays: Saudi Arabia
ID NLM: 9705695

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 24 02 2020
accepted: 18 04 2020
entrez: 20 6 2020
pubmed: 20 6 2020
medline: 20 6 2020
Statut: ppublish

Résumé

The bronchodilator effects of Roflumilast "a selective phosphodiesterase type-4 (PDE4)" inhibitor studied in this experimental protocol. The spiral strips of isolated guinea-pig tracheal chains mounted in organ bath and maintained in Krebs solution ventilated with carbogen at 32 °C and in Ca

Identifiants

pubmed: 32550801
doi: 10.1016/j.jsps.2020.04.011
pii: S1319-0164(20)30089-X
pmc: PMC7292871
doi:

Types de publication

Journal Article

Langues

eng

Pagination

698-702

Informations de copyright

© 2020 The Author(s).

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Auteurs

Faisal Imam (F)

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Najeeb Ur Rehman (NU)

Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.

Mohd Nazam Ansari (MN)

Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.

Wajhul Qamar (W)

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Central Laboratory; Research Center, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Muhammad Afzal (M)

Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah 72341, Saudi Arabia.

Khalid Saad Alharbi (KS)

Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah 72341, Saudi Arabia.

Classifications MeSH