Formulation and optimization of liquisolid compact for enhancing dissolution properties of efavirenz by using DoE approach.
Carrier coater ratio
DoE approach
Efavirenz
Liquid loading factor
Liquisolid technique
Optimization
Journal
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
ISSN: 1319-0164
Titre abrégé: Saudi Pharm J
Pays: Saudi Arabia
ID NLM: 9705695
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
20
12
2019
accepted:
29
04
2020
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
20
6
2020
Statut:
ppublish
Résumé
Efavirenz displays low and variable bioavailability because of its poor aqueous solubility and high log P-value. The present investigation was aimed to improve the dissolution profile of efavirenz by using a simple, scalable and cost-effective technique of liquisolid compact. The drug was dissolved in Trancutol-HP for preparing the liquid medicament which was subsequently mixed with carrier and coating material to make free-flowing and compressible powder. 3
Identifiants
pubmed: 32550806
doi: 10.1016/j.jsps.2020.04.016
pii: S1319-0164(20)30102-X
pmc: PMC7292870
doi:
Types de publication
Journal Article
Langues
eng
Pagination
737-745Informations de copyright
© 2020 Published by Elsevier B.V. on behalf of King Saud University.
Déclaration de conflit d'intérêts
The authors declared that there is no conflict of interest.
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