Typhim vi immunization assists to discriminate primary antibody responses in hematological malignancies.
Hematological Malignancies
Pneumo 23
Primary responses
ROC curve
Typhim Vi
Union index, cut-off value
Youden index
secondary responses
specific polysaccharide Ab response
Journal
MethodsX
ISSN: 2215-0161
Titre abrégé: MethodsX
Pays: Netherlands
ID NLM: 101639829
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
12
2019
accepted:
20
05
2020
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
20
6
2020
Statut:
epublish
Résumé
Assessment of specific antibody (Ab) production to polysaccharide antigens is clinically relevant, identifying patients at risk for infection by encapsulated bacteria and thus enabling a more rigorous selection of patients that can benefit of immunoglobulin replacement therapy. Classically, the gold-standard test is the measurement of antibody production to pure polysaccharide pneumococcal (PPV) immunization. Several factors, including introduction of conjugate vaccination schedule, serotyping analysis, high baseline Ab levels, have hindered the evaluation of polysaccharide antigens. This is even more difficult in secondary immunodeficiencies (SID), where patients can show secondary responses despite lack of primary antibody responses and present with recurrent or severe infections. Assessment of specific Ab production to pure S
Identifiants
pubmed: 32551240
doi: 10.1016/j.mex.2020.100936
pii: S2215-0161(20)30156-4
pii: 100936
pmc: PMC7289764
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100936Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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