Optical coherence tomography angiography findings in macular toxoplasma retinochoroiditis: A case report.
Intravitreal clindamycin
Macula
Optical coherence tomography angiography
Toxoplasma retinochoroiditis
Journal
American journal of ophthalmology case reports
ISSN: 2451-9936
Titre abrégé: Am J Ophthalmol Case Rep
Pays: United States
ID NLM: 101679941
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
13
07
2019
revised:
18
01
2020
accepted:
31
05
2020
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
20
6
2020
Statut:
epublish
Résumé
To report the optical coherence tomography angiography (OCT-A) findings in a patient with macular toxoplasma retinochoroiditis (TRC). A 14-year old female presented with a 2-week history of decreased vision of her right eye. Upon presentation, on the right eye, visual acuity was 20/200 and the fundus revealed 2+ vitritis and an active parafoveal area of retinitis superotemporally. Toxoplasma serology revealed positive IgG and negative IgM. Initial treatment consisted of intravitreal clindamycin (1.0mg in 0.1 mL) with dexamethasone (1.0 mg in 0.1 mL) along with oral trimethoprim/sulfamethoxazole, azithromycin and prednisone; of which the trimethoprim/sulfamethoxazole was discontinued 4 days into therapy due to a pruritic rash. Six-weeks after the presentation, the oral prednisone had been tapered off, and all therapy discontinued. The patient had complete resolution of TRC and recovered 20/20 vision. OCT-A analysis of the right macula, performed after completion of treatment, revealed preservation of foveal perfusion along a parafoveal area of ischemia, superotemporally, at the superficial and deep retinal vascular complexes, including the choriocapillaris. In macular TRC, OCT-A may help to assess therapeutic outcomes from a vascular perspective. To our knowledge, our case represents the first description in the medical literature of OCT-A findings in macular TRC.
Identifiants
pubmed: 32551402
doi: 10.1016/j.ajoc.2020.100764
pii: S2451-9936(20)30115-8
pii: 100764
pmc: PMC7287232
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100764Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The following authors have no financial disclosures: AP, RL, AE, AO.
Références
Clin Exp Ophthalmol. 2013 Jan-Feb;41(1):95-108
pubmed: 22712598
BMJ Case Rep. 2016 Jan 11;2016:
pubmed: 26759399
Arch Ophthalmol. 1969 Apr;81(4):481-93
pubmed: 5777756
Acta Trop. 2018 Sep;185:52-62
pubmed: 29704469
Opt Express. 2007 Apr 2;15(7):4083-97
pubmed: 19532651
Int Ophthalmol. 1998-1999;22(2):85-8
pubmed: 10472767
Am J Ophthalmol. 1993 Apr 15;115(4):517-23
pubmed: 8470726
Clin Ophthalmol. 2017 Dec 01;11:2133-2137
pubmed: 29238162
Br J Ophthalmol. 1998 Nov;82(11):1306-8
pubmed: 9924338
Biomed Opt Express. 2017 Jan 24;8(2):1056-1082
pubmed: 28271003
J Curr Ophthalmol. 2016 Dec 28;29(2):120-125
pubmed: 28626822
Ophthalmology. 2005 Nov;112(11):1876-82
pubmed: 16171866
Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1157-61
pubmed: 15037582
Prog Retin Eye Res. 2017 Sep;60:66-100
pubmed: 28760677
Am J Ophthalmol. 2004 Jan;137(1):1-17
pubmed: 14700638
J Biomed Opt. 2015 Oct;20(10):100901
pubmed: 26473588
J Ophthalmol. 2014;2014:273506
pubmed: 25197557
Ophthalmology. 2011 Jan;118(1):134-41
pubmed: 20708269
Ophthalmic Surg Lasers Imaging Retina. 2015 Jan;46(1):137-40
pubmed: 25559528
Korean J Parasitol. 2013 Aug;51(4):393-9
pubmed: 24039281
Ophthalmic Surg Lasers. 2001 May-Jun;32(3):183-92
pubmed: 11371084
Arq Bras Oftalmol. 2016 May-Jun;79(3):189-91
pubmed: 27463632
Ophthalmology. 2013 Feb;120(2):371-8
pubmed: 23062648
Am J Trop Med Hyg. 2010 Mar;82(3):464-5
pubmed: 20207874
J Ophthalmol. 2018 Feb 12;2018:4160837
pubmed: 29619254
PLoS Negl Trop Dis. 2016 May 02;10(5):e0004685
pubmed: 27136081