Controlled Functional Zonation of Hepatocytes
Animals
Cell Line
Dependovirus
/ genetics
Down-Regulation
/ drug effects
Doxycycline
/ pharmacology
Genetic Engineering
Genetic Vectors
/ genetics
Hepacivirus
/ genetics
Hepatocytes
/ cytology
Mice
Microtubule-Associated Proteins
/ genetics
Up-Regulation
/ drug effects
Wnt Signaling Pathway
/ genetics
beta Catenin
/ genetics
HCV
bimodal expression
external control of hepatic phenotype
liver zonation
modulation of hepatic metabolism
mosaicism
pericentral
periportal
single-cell heterogeneity
virus susceptibility
Journal
ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075
Informations de publication
Date de publication:
17 07 2020
17 07 2020
Historique:
pubmed:
20
6
2020
medline:
28
5
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Key liver functions, including protein synthesis, carbohydrate metabolism, and detoxification, are performed by specific populations of hepatocytes that are defined by their relative positions within the liver lobules. On a molecular level, the functional heterogeneity with periportal and pericentral phenotypes, so-called metabolic liver zonation, is mainly established by a gradient of canonical Wnt signaling activity. Since the relevant physiological cues are missing in
Identifiants
pubmed: 32551516
doi: 10.1021/acssynbio.9b00435
doi:
Substances chimiques
Microtubule-Associated Proteins
0
beta Catenin
0
Doxycycline
N12000U13O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM