Diacetoxy iodobenzene mediated regioselective synthesis and characterization of novel [1,2,4]triazolo[4,3-a]pyrimidines: apoptosis inducer, antiproliferative activities and molecular docking studies.

Antineoplastic Agents / pharmacology Apoptosis Drug Screening Assays, Antitumor Humans Iodobenzenes / pharmacology Molecular Docking Simulation Molecular Structure Pyrimidines / pharmacology Structure-Activity Relationship
[1,2,4]triazolo[4,3-a]pyrimidines antiproliferative activity apoptosis regioselective thymidylate synthase

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
Aug 2021
Historique:
pubmed: 20 6 2020
medline: 12 8 2021
entrez: 20 6 2020
Statut: ppublish

Résumé

Prompt and regioselective synthesis of eleven novel [1,2,4]triazolo[4,3-a]pyrimidines

Identifiants

DOI: 10.1080/07391102.2020.1777900 PMID: 32552396
pubmed: 32552396
doi: 10.1080/07391102.2020.1777900
doi:

Substances chimiques

Antineoplastic Agents 0
Iodobenzenes 0
Pyrimidines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4398-4414

Auteurs

Raj Kamal (R)

Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India.

Ravinder Kumar (R)

Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India.

Vipan Kumar (V)

Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India.

Jitender K Bhardwaj (JK)

Department of Zoology, Kurukshetra University, Kurukshetra, Haryana, India.

Priyanka Saraf (P)

Department of Zoology, Kurukshetra University, Kurukshetra, Haryana, India.

Ajay Kumar (A)

Department of Botanical & Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Kritika Pandit (K)

Department of Botanical & Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Satwinderjeet Kaur (S)

Department of Botanical & Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Prabhakar Chetti (P)

Department of Chemistry, National Institute of Technology (NIT), Kurukshetra, Haryana, India.

Satyajit Beura (S)

Department of Chemistry, National Institute of Technology (NIT), Kurukshetra, Haryana, India.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures iodés › Iodobenzènes › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Diacetoxy iodobenzene mediated regioselective...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Diacetoxy iodobenzene mediated regioselective...