Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.
COVID-19
Neuroinflammation
SARS-CoV-2
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
18 Jun 2020
18 Jun 2020
Historique:
received:
01
05
2020
accepted:
01
06
2020
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
25
6
2020
Statut:
epublish
Résumé
COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.
Sections du résumé
BACKGROUND
BACKGROUND
COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.
CASE PRESENTATION
METHODS
We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion.
CONCLUSION
CONCLUSIONS
Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.
Identifiants
pubmed: 32552792
doi: 10.1186/s12883-020-01812-2
pii: 10.1186/s12883-020-01812-2
pmc: PMC7301053
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
248Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI157488
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH118999
Pays : United States
Organisme : NIMH NIH HHS
ID : K23MH118999
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001864
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121207
Pays : United States
Commentaires et corrections
Type : UpdateOf
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