[Clinical Characteristics and Prognostic Influencing Factors of Adult AML Patients with MLL Rearrangement].

To investigate the clinical characteristics and prognostic influencing factors of adult AML patients with MLL rearrangement. Clinical data of 184 adult AML patients with MLL rearrangement treated in our hospital from January 2011 to December 2017 were analyzed retrospectively. The clinical features, immunophenotypic characteristics, cytogenetic characteristics, molecular biological characteristics and gene mutation characteristics were recorded, the survival and prognostic influencing factors of patients were analyzed. Among 184 patients, 94 cases were male, 90 cases were female, median age were 36.0 years, median WBC count were 22.0×10 Adult AML patients with MLL rearrangement are mostly belong to acute monocytic leukemia, and MLL/AF9 is the most common associated gene. Patients with AML and MLL rearrangement are prone to recurrence after routine chemotherapy. Allo-HSCT treatment is helpful to improve clinical prognosis of patients. 成人AML伴MLL重排患者临床特征及预后影响因素探讨. 探讨成人急性髓系白血病（AML）伴混合谱系白血病（MLL）重排患者临床特征及预后影响因素. 回顾性分析本院2011年1月-2017年12月收治的184例成人AML伴MLL重排患者的临床资料，记录其临床特征、免疫表型特征、细胞遗传学特征、分子生物学特征及基因突变特征，分析患者生存情况及预后影响因素. 184例患者中男性94例，女性90例，中位年龄为36.0岁，中位白细胞（white blood cell，WBC）计数为22.0×10 成人AML伴MLL重排患者多属于急性单核细胞白血病，伴随基因中以MLL/AF9最为常见；该类患者常规化疗后较易复发，行异基因造血干细胞移植（allo-HSCT）治疗有助于改善患者的临床预后.