Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications.
Antibodies, Viral
/ blood
Betacoronavirus
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
/ methods
Coronaviridae Infections
/ diagnosis
Coronavirus
/ immunology
Coronavirus Infections
/ diagnosis
Humans
Immunoglobulin G
/ blood
Immunoglobulin M
/ blood
Pandemics
Pneumonia, Viral
/ diagnosis
Predictive Value of Tests
SARS-CoV-2
Sensitivity and Specificity
Serologic Tests
/ methods
Severe Acute Respiratory Syndrome
/ blood
SARS-CoV-2
meta-analysis
predictive values
sensitivity
serological tests
specificity
systematic review
Journal
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
27
6
2020
Statut:
ppublish
Résumé
We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
Identifiants
pubmed: 32553061
doi: 10.2807/1560-7917.ES.2020.25.23.2000980
pmc: PMC7403641
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Références
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