Role of efflux in enhancing butanol tolerance of bacteria.
1-butanol efflux
Butanol toxicity
Efflux pumps
Journal
Journal of biotechnology
ISSN: 1873-4863
Titre abrégé: J Biotechnol
Pays: Netherlands
ID NLM: 8411927
Informations de publication
Date de publication:
20 Aug 2020
20 Aug 2020
Historique:
received:
01
11
2019
revised:
02
06
2020
accepted:
12
06
2020
pubmed:
20
6
2020
medline:
9
2
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
N-butanol, a valued solvent and potential fuel extender, could possibly be produced by fermentation using either native producers, i.e. solventogenic Clostridia, or engineered platform organisms such as Escherichia coli or Pseudomonas species, if the main process obstacle, a low final butanol concentration, could be overcome. A low final concentration of butanol is the result of its high toxicity to production cells. Nevertheless, bacteria have developed several mechanisms to cope with this toxicity and one of them is active butanol efflux. This review presents information about a few well characterized butanol efflux pumps from Gram-negative bacteria (P. putida and E. coli) and summarizes knowledge about putative butanol efflux systems in Gram-positive bacteria.
Identifiants
pubmed: 32553531
pii: S0168-1656(20)30155-3
doi: 10.1016/j.jbiotec.2020.06.008
pii:
doi:
Substances chimiques
AcrAB-TolC protein, E coli
0
Bacterial Proteins
0
Carrier Proteins
0
Escherichia coli Proteins
0
Membrane Transport Proteins
0
Solvents
0
SrpB protein, Pseudomonas putida
0
1-Butanol
8PJ61P6TS3
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-27Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.