Activation of μ-opioid receptors differentially affects the preBötzinger Complex and neighbouring regions of the respiratory network in the adult rabbit.
Analgesics, Opioid
/ pharmacology
Animals
Apnea
/ chemically induced
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
/ pharmacology
Medulla Oblongata
/ drug effects
Microinjections
Naloxone
/ pharmacology
Narcotic Antagonists
/ pharmacology
Neurons
Phrenic Nerve
/ drug effects
Rabbits
Receptors, Opioid, mu
/ agonists
Respiratory Center
/ drug effects
Respiratory Insufficiency
/ chemically induced
Control of breathing
Medullary respiratory network
Opioid-induced respiratory depression
preBötzinger Complex
μ-Opioid receptors
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
16
03
2020
revised:
05
06
2020
accepted:
12
06
2020
pubmed:
20
6
2020
medline:
6
10
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
The role of the different components of the respiratory network in the mediation of opioid-induced respiratory depression is still unclear. We investigated the contribution of the preBötzinger Complex (preBötC) and the neighbouring Bötzinger Complex (BötC) and inspiratory portion of the ventral respiratory group (iVRG) in anesthetized, vagotomized, paralyzed and artificially ventilated adult rabbits making use of bilateral microinjections (30-50 nl) of the μ-opioid receptor agonist [D-Ala
Identifiants
pubmed: 32553889
pii: S1569-9048(20)30140-3
doi: 10.1016/j.resp.2020.103482
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Narcotic Antagonists
0
Receptors, Opioid, mu
0
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
100929-53-1
Naloxone
36B82AMQ7N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103482Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.