High inter-species differences of 12378-polychlorinated dibenzo-p-dioxin between humans and mice.
Elimination rate
Half-life
Interspecies differences
PBPK model
Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans
Journal
Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
04
03
2020
revised:
27
05
2020
accepted:
03
06
2020
pubmed:
20
6
2020
medline:
19
8
2020
entrez:
20
6
2020
Statut:
ppublish
Résumé
Although huge interspecies differences in the response to dioxins have been acknowledged, toxic equivalency factors derived from rodent studies are often used to assess human health risk. To determine interspecies differences, we first developed a toxicokinetic model in humans by measuring dioxin concentrations in environmental and biomonitoring samples from Southern China. Significant positive correlations between dioxin concentrations in blood and age were observed for seven dioxin congeners, indicating an age-dependent elimination rate. Based on toxicokinetic models in humans, the half-lives of 15 dioxin congeners were estimated to be 1.60-28.55 years. In consideration that the highest contribution to total toxic equivalency in blood samples was by 12378-polychlorinated dibenzo-p-dioxin (P
Identifiants
pubmed: 32554089
pii: S0269-7491(20)31617-1
doi: 10.1016/j.envpol.2020.114957
pii:
doi:
Substances chimiques
Benzofurans
0
Dibenzofurans, Polychlorinated
0
Dioxins
0
Polychlorinated Dibenzodioxins
0
Polychlorinated Biphenyls
DFC2HB4I0K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114957Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest All authors declare no competing interests. The authors declare they have no actual or potential competing financial interests.