Auditory neurophysiology reveals central nervous system dysfunction in HIV-infected individuals.
Auditory neurophysiology
Auditory processing
Electrophysiology
Frequency-following response
HIV
Journal
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
ISSN: 1872-8952
Titre abrégé: Clin Neurophysiol
Pays: Netherlands
ID NLM: 100883319
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
23
09
2019
revised:
02
04
2020
accepted:
08
04
2020
pubmed:
20
6
2020
medline:
25
5
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
To test the hypothesis that human immunodeficiency virus (HIV) affects auditory-neurophysiological functions. A convenience sample of 68 HIV+ and 59 HIV- normal-hearing adults was selected from a study set in Dar es Salaam, Tanzania. The speech-evoked frequency-following response (FFR), an objective measure of auditory function, was collected. Outcome measures were FFRs to the fundamental frequency (F0) and to harmonics corresponding to the first formant (F1), two behaviorally relevant cues for understanding speech. The HIV+ group had weaker responses to the F1 than the HIV- group; this effect generalized across multiple stimuli (d = 0.59). Responses to the F0 were similar between groups. Auditory-neurophysiological responses differ between HIV+ and HIV- adults despite normal hearing thresholds. The FFR may reflect HIV-associated central nervous system dysfunction that manifests as disrupted auditory processing of speech harmonics corresponding to the first formant.
Identifiants
pubmed: 32554244
pii: S1388-2457(20)30327-8
doi: 10.1016/j.clinph.2020.04.165
pmc: PMC7363550
mid: NIHMS1596690
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1827-1832Subventions
Organisme : FIC NIH HHS
ID : D43 TW009573
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC009972
Pays : United States
Informations de copyright
Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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