Obstructive sleep apnoea and cognitive decline in mild-to-moderate Alzheimer's disease.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
05
03
2020
accepted:
09
06
2020
pubmed:
20
6
2020
medline:
22
6
2021
entrez:
20
6
2020
Statut:
epublish
Résumé
We evaluated the influence of untreated obstructive sleep apnoea (OSA) on the magnitude of cognitive decline and on several cognitive subdomains in patients with mild-to-moderate Alzheimer's disease.In this single-centre study, 144 patients were recruited prospectively from a cognitive impairment unit and underwent overnight polysomnography.The mean±sd change in the Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) score at 12 months was 3.19±5.61 in the non-OSA group and 0.08±5.62 in the OSA group, with an intergroup difference of -3.36 (95% CI 0.19-0.16; p=0.002). We did not observe a significant difference in any cognitive subdomains at 12 months. Regarding Mini-Mental State Examination scores at 36 months, the mean change was 1.69 (95% CI -1.26-4.64; p=0.445). No significant differences were found among different OSA severity groups.We observed that ADAS-cog scores were better in the OSA group than in the non-OSA group by a statistically but not clinically significant margin. We did not find differences in the different cognitive subdomains after 1 year or in global cognition after 3 years of follow-up.
Identifiants
pubmed: 32554539
pii: 13993003.00523-2020
doi: 10.1183/13993003.00523-2020
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02814045']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: C. Jorge has nothing to disclose. Conflict of interest: A. Targa has nothing to disclose. Conflict of interest: I.D. Benítez has nothing to disclose. Conflict of interest: F. Dakterzada has nothing to disclose. Conflict of interest: G. Torres has nothing to disclose. Conflict of interest: O. Minguez has nothing to disclose. Conflict of interest: A. Carnes has nothing to disclose. Conflict of interest: M. Pujol has nothing to disclose. Conflict of interest: A. Gibert has nothing to disclose. Conflict of interest: R. López has nothing to disclose. Conflict of interest: A.M. Gaeta has nothing to disclose. Conflict of interest: M. Dalmases has nothing to disclose. Conflict of interest: R. Farré has nothing to disclose. Conflict of interest: M. Sánchez-de-la-Torre has nothing to disclose. Conflict of interest: F. Barbé has nothing to disclose. Conflict of interest: G. Piñol-Ripoll has nothing to disclose.