Spontaneous Tumor Regression in Tasmanian Devils Associated with
cancer
gene expression
tumor regression
tumor suppressor
Journal
Genetics
ISSN: 1943-2631
Titre abrégé: Genetics
Pays: United States
ID NLM: 0374636
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
05
05
2020
accepted:
12
06
2020
pubmed:
20
6
2020
medline:
7
7
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Spontaneous tumor regression has been documented in a small proportion of human cancer patients, but the specific mechanisms underlying tumor regression without treatment are not well understood. Tasmanian devils are threatened with extinction from a transmissible cancer due to universal susceptibility and a near 100% case fatality rate. In over 10,000 cases, <20 instances of natural tumor regression have been detected. Previous work in this system has focused on Tasmanian devil genetic variation associated with the regression phenotype. Here, we used comparative and functional genomics to identify tumor genetic variation associated with tumor regression. We show that a single point mutation in the 5' untranslated region of the putative tumor suppressor
Identifiants
pubmed: 32554701
pii: genetics.120.303428
doi: 10.1534/genetics.120.303428
pmc: PMC7404226
doi:
Substances chimiques
Monomeric GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1143-1152Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM103324
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126563
Pays : United States
Informations de copyright
Copyright © 2020 by the Genetics Society of America.
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