The role of the adenosine triphosphate-sensitive potassium channels in pinacidil-induced vasodilatation of the human saphenous vein in patients with and without type 2 diabetes mellitus.

Aged Diabetes Mellitus, Type 2 / metabolism Dose-Response Relationship, Drug Female Humans KATP Channels / metabolism Male Middle Aged Organ Culture Techniques Pinacidil / pharmacology Saphenous Vein / drug effects Vasodilation / drug effects Vasodilator Agents / pharmacology

Journal

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
ISSN: 1899-1505
Titre abrégé: J Physiol Pharmacol
Pays: Poland
ID NLM: 9114501

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 16 01 2020
accepted: 28 02 2020
entrez: 20 6 2020
pubmed: 20 6 2020
medline: 26 1 2021
Statut: ppublish

Résumé

Type 2 diabetes mellitus (T2DM) increases cardiovascular complications. Diabetic vascular dysfunction is associated with the reduced activity of the different smooth muscle potassium (K

Identifiants

DOI: 10.26402/jpp.2020.1.12 PMID: 32554847
pubmed: 32554847
doi: 10.26402/jpp.2020.1.12
doi:

Substances chimiques

KATP Channels 0
Vasodilator Agents 0
Pinacidil 7B0ZZH8P2W

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

J Rajkovic (J)

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade, Serbia. jolarajkovic@yahoo.com.

M Peric (M)

Dedinje Cardiovascular Institute, Belgrade, Serbia.

J Stanisic (J)

Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.

R Novakovic (R)

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade, Serbia.

V Djokic (V)

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade, Serbia.

J Rakocevic (J)

Institute of Histology and Embryology, Medical Faculty, University of Belgrade, Belgrade, Serbia.

S Tepavcevic (S)

Laboratory for Molecular Biology and Endocrinology, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.

M Labudovic-Borovic (M)

Institute of Histology and Embryology, Medical Faculty, University of Belgrade, Belgrade, Serbia.

M Gostimirovic (M)

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade, Serbia.

H Heinle (H)

Institute of Physiology, University of Tubingen, Germany.

L Gojkovic-Bukarica (L)

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade, Serbia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The role of the adenosine...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › The role of the adenosine...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › The role of the adenosine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The role of the adenosine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Canaux KATP › The role of the adenosine...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The role of the adenosine...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture d'organes › The role of the adenosine...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Pinacidil › The role of the adenosine...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Veines › Veine saphène › The role of the adenosine...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › The role of the adenosine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Vasodilatateurs › The role of the adenosine...