The complement system in COVID-19: friend and foe?
Journal
JCI insight
ISSN: 2379-3708
Titre abrégé: JCI Insight
Pays: United States
ID NLM: 101676073
Informations de publication
Date de publication:
06 08 2020
06 08 2020
Historique:
pubmed:
20
6
2020
medline:
18
8
2020
entrez:
20
6
2020
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality have been attributed to an exaggerated immune response. The role of complement activation and its contribution to illness severity is being increasingly recognized. Here, we summarize current knowledge about the interaction of coronaviruses with the complement system. We posit that (a) coronaviruses activate multiple complement pathways; (b) severe COVID-19 clinical features often resemble complementopathies; (c) the combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19; (d) a subset of patients with COVID-19 may have a genetic predisposition associated with complement dysregulation; and (e) these observations create a basis for clinical trials of complement inhibitors in life-threatening illness.
Identifiants
pubmed: 32554923
pii: 140711
doi: 10.1172/jci.insight.140711
pmc: PMC7455060
doi:
pii:
Banques de données
ClinicalTrials.gov
['NCT04369469']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL148510
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM099111
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136352
Pays : United States
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