Analysis of the sperm flagellar axoneme using gene-modified mice.
central pair
chimeric mice
male fertility
Journal
Experimental animals
ISSN: 1881-7122
Titre abrégé: Exp Anim
Pays: Japan
ID NLM: 9604830
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
pubmed:
20
6
2020
medline:
24
11
2020
entrez:
20
6
2020
Statut:
ppublish
Résumé
Infertility is a global health issue that affects 1 in 6 couples, with male factors contributing to 50% of cases. The flagellar axoneme is a motility apparatus of spermatozoa, and disruption of its structure or function could lead to male infertility. The axoneme consists of a "9+2" structure that contains a central pair of two singlet microtubules surrounded by nine doublet microtubules, in addition to several macromolecular complexes such as dynein arms, radial spokes, and nexin-dynein regulatory complexes. Molecular components of the flagellar axoneme are evolutionally conserved from unicellular flagellates to mammals, including mice. Although knockout (KO) mice have been generated to understand their function in the formation and motility regulation of sperm flagella, the majority of KO mice die before sexual maturation due to impaired ciliary motility, which makes it challenging to analyze mature spermatozoa. In this review, we introduce methods that have been used to overcome premature lethality, focusing on KO mouse lines of central pair components.
Identifiants
pubmed: 32554934
doi: 10.1538/expanim.20-0064
pmc: PMC7677079
doi:
Substances chimiques
Microtubule-Associated Proteins
0
microtubule nexin
0
Dyneins
EC 3.6.4.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
374-381Références
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