Genetic breakdown of a Tet-off conditional lethality system for insect population control.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 06 2020
18 06 2020
Historique:
received:
09
03
2020
accepted:
19
05
2020
entrez:
20
6
2020
pubmed:
20
6
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Genetically modified conditional lethal strains have been created to improve the control of insect pest populations damaging to human health and agriculture. However, understanding the potential for the genetic breakdown of lethality systems by rare spontaneous mutations, or selection for inherent suppressors, is critical since field release studies are in progress. This knowledge gap was addressed in a Drosophila tetracycline-suppressible embryonic lethality system by analyzing the frequency and structure of primary-site spontaneous mutations and second-site suppressors resulting in heritable survivors from 1.2 million zygotes. Here we report that F
Identifiants
pubmed: 32555259
doi: 10.1038/s41467-020-16807-3
pii: 10.1038/s41467-020-16807-3
pmc: PMC7303202
doi:
Substances chimiques
Drosophila Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3095Références
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