Natural history of peripheral nerve schwannomas.

Adult Female Humans Male Middle Aged Neurilemmoma / diagnostic imaging Neurofibromatoses / diagnostic imaging Peripheral Nervous System Diseases / diagnostic imaging Skin Neoplasms / diagnostic imaging
Natural history, tumor growth Neurofibromatosis Peripheral nerve Schwannoma Schwannomatosis

Journal

Acta neurochirurgica
ISSN: 0942-0940
Titre abrégé: Acta Neurochir (Wien)
Pays: Austria
ID NLM: 0151000

Informations de publication

Date de publication:
08 2020
Historique:
received: 01 05 2020
accepted: 22 05 2020
pubmed: 20 6 2020
medline: 6 1 2021
entrez: 20 6 2020
Statut: ppublish

Résumé

Little information about the natural history of peripheral nerve schwannomas exists in the literature. The aim of this study was to determine the natural history of those tumors both in sporadic and schwannomatosis cases to determine their growth rates and patterns. In 44 patients from 3 surgical centers, hospital charts, follow-up records, and imaging studies were reviewed. Of these patients, 7 had sporadic schwannomatosis. Histological diagnosis was obtained in 37 patients (84%). Tumor growth rates were determined by calculating the absolute and relative growth rates. On the 47 tumors analyzed, the median tumor size at diagnosis was 1.8 cm This study confirms the slow-growing nature of most, but not all, peripheral nerve schwannomas. Additional studies are mandatory to explore the environmental factors influencing growth in sporadic cases and the precise growth patterns in schwannomatosis cases to detect the rare cases of malignant transformation and pave the way to the evaluation of future clinical trials.

Sections du résumé

BACKGROUND
Little information about the natural history of peripheral nerve schwannomas exists in the literature. The aim of this study was to determine the natural history of those tumors both in sporadic and schwannomatosis cases to determine their growth rates and patterns.
METHODS
In 44 patients from 3 surgical centers, hospital charts, follow-up records, and imaging studies were reviewed. Of these patients, 7 had sporadic schwannomatosis. Histological diagnosis was obtained in 37 patients (84%). Tumor growth rates were determined by calculating the absolute and relative growth rates.
RESULTS
On the 47 tumors analyzed, the median tumor size at diagnosis was 1.8 cm
CONCLUSION
This study confirms the slow-growing nature of most, but not all, peripheral nerve schwannomas. Additional studies are mandatory to explore the environmental factors influencing growth in sporadic cases and the precise growth patterns in schwannomatosis cases to detect the rare cases of malignant transformation and pave the way to the evaluation of future clinical trials.

Identifiants

DOI: 10.1007/s00701-020-04430-6 PMID: 32556523
pubmed: 32556523
doi: 10.1007/s00701-020-04430-6
pii: 10.1007/s00701-020-04430-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1883-1889

Auteurs

Laila El Sayed (L)

Hand and Upper Extremity Surgery Unit, European Hospital Georges Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75908, Paris Cedex 15, France.
Faculté de Pharmacie de Paris, Université Paris Descartes-Sorbonne, Paris Cité, Paris, France.

Emmanuel H Masmejean (EH)

Hand and Upper Extremity Surgery Unit, European Hospital Georges Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75908, Paris Cedex 15, France.
Faculté de Pharmacie de Paris, Université Paris Descartes-Sorbonne, Paris Cité, Paris, France.
Clinique Blomet - Research Unit, Paris, France.

Beatrice Parfait (B)

Faculté de Pharmacie de Paris, Université Paris Descartes-Sorbonne, Paris Cité, Paris, France.
Service de Génétique et Biologie Moléculaires, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.

Michel Kalamarides (M)

Department of Neurosurgery, Bâtiment Babinski, Groupe Hospitalier Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris, Sorbonne Universités, 47-83 boulevard de l'Hôpital, 75013, Paris, France.
Genetics and Development of Brain Tumors - CRICM INSERM U1127 CNRS UMR 7225, Bâtiment ICM 4ème étage - Hôpital de la Pitié-Salpêtrière, Paris, France.

David Biau (D)

Faculté de Pharmacie de Paris, Université Paris Descartes-Sorbonne, Paris Cité, Paris, France.
Department of orthopedic surgery, Université Paris-Descartes, Hôpital Cochin, Assistance publique-Hôpitaux de Paris, Paris, France.

Matthieu Peyre (M)

Department of Neurosurgery, Bâtiment Babinski, Groupe Hospitalier Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris, Sorbonne Universités, 47-83 boulevard de l'Hôpital, 75013, Paris, France. matthieu.peyre@aphp.fr.
Genetics and Development of Brain Tumors - CRICM INSERM U1127 CNRS UMR 7225, Bâtiment ICM 4ème étage - Hôpital de la Pitié-Salpêtrière, Paris, France. matthieu.peyre@aphp.fr.
ORCID: 0000-0001-8470-9516

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Natural history of peripheral nerve schwannomas.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Natural history of peripheral nerve schwannomas.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Natural history of peripheral nerve schwannomas.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Neurinome › Natural history of peripheral nerve schwannomas.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Syndromes néoplasiques héréditaires › Neurofibromatoses › Natural history of peripheral nerve schwannomas.
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Neuropathies périphériques › Natural history of peripheral nerve schwannomas.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Natural history of peripheral nerve schwannomas.