Predictive value of the sentinel lymph node procedure in the staging of non-metastatic colorectal cancer.
Adjuvant chemotherapy
Colorectal cancer
Indocyanine green
Micrometastases
Sentinel lymph node
Upstaging
Journal
International journal of colorectal disease
ISSN: 1432-1262
Titre abrégé: Int J Colorectal Dis
Pays: Germany
ID NLM: 8607899
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
accepted:
25
05
2020
pubmed:
20
6
2020
medline:
24
6
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Despite the recent growing interest of the scientific community, there is still no consensus on the actual applicability and effectiveness of sentinel lymph node (SL) procedure in colon cancers. This study aims to quantify feasibility, detection rate, negative predictive value, and accuracy of the SL identified with fluorescent dye in early colon cancers (ECC). This study conducted a consecutive sampling of 95 patients with non-metastatic colorectal cancer who have been treated with laparoscopic colon resection and complete mesocolic excision after a 25-mg indocyanine green peritumoral laparoscopic injection and SL identification with a near-infrared camera. The SL was later isolated and sent to ultra-staging. Ninety-five patients with an average age of 71 (range 37-90) and a mean BMI of 25 (range 18-39) have been recruited. On the patient sample (92 Pts), an average of 1.49 SL (range 1-5) and a mean time of 4 min were identified. The detection rate was 96.8% and the negative predictive value and accuracy rates were 96.2% and 93.4%, respectively. Mapping the SL with fluorescent dye can play an important role in the treatment of colon cancers, particularly those at early stages, and can lead to ultra-conservative surgery.
Identifiants
pubmed: 32556650
doi: 10.1007/s00384-020-03654-3
pii: 10.1007/s00384-020-03654-3
doi:
Substances chimiques
Indocyanine Green
IX6J1063HV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1921-1928Références
O’Connell JB, Maggard MA, Ko CY (2004) Colon cancer survival rates with the new American Joint Committee on cancer sixth edition staging. J Natl Cancer Inst 96(19):1420–1425
pubmed: 15467030
doi: 10.1093/jnci/djh275
Marshall JL, Haller DG, de Gramont A, Hochster HS, Lenz HJ, Ajani JA, Goldberg RM (2007) Adjuvant therapy for stage ii and iii colon cancer: consensus report of the International Society of Gastrointestinal Oncology. J Gastrointest Cancer Res 1(4):146–154
Wolpin BM, Mayer RJ (2008) Systemic treatment of colorectal cancer. Gastroenterology 134(5):1296–1310. https://doi.org/10.1053/j.gastro.2008.02.098
pubmed: 18471507
pmcid: 2528832
doi: 10.1053/j.gastro.2008.02.098
Lahaye MJ, Engelen SM, Nelemans PJ, Beets GL, van de Velde CJ, van Engelshoven JM, Beets-Tan RG (2005) Imaging for predicting the risk factors--the circumferential resection margin and nodal disease--of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 26:259–268
pubmed: 16152740
doi: 10.1053/j.sult.2005.04.005
Hao F, Xue-wei Z, Zhuo Z, Ding-pei H, Zhi-hai M, Ai-Guo L, Thasler WE (2016) Laparoscopic complete mesocolic excision for stage ii/iii left-sided colon cancers: a prospective study and comparison with D3 lymph node dissection. J Laparoendosc Adv Surg Tech A. 26(8):606–613. https://doi.org/10.1089/lap.2016.0120
doi: 10.1089/lap.2016.0120
Böckelman C, Engelmann BE, Kaprio T, Hansen TF, Glimelius B (2015) Risk of recurrence in patients with colon cancer stage II and III: a systematic review and meta-analysis of recent literature. Acta Oncol 54(1):5–16. https://doi.org/10.3109/0284186X.2014.975839
pubmed: 25430983
doi: 10.3109/0284186X.2014.975839
van der Pas MH, Meijer S, Hoekstra OS, Riphagen II, de Vet HC, Knol DL, van Grieken NC, Meijerink WJ (2011) Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis. Lancet Oncol 12(6):540–550. https://doi.org/10.1016/S1470-2045(11)70075-4
pubmed: 21549638
doi: 10.1016/S1470-2045(11)70075-4
Kanamoto T, Matsuki M, Okuda J, Inada Y, Tatsugami F, Tanikake M, Yoshikawa S, Narabayashi I, Kawasaki H, Tanaka K, Yamamoto T, Tanigawa N, Egashira Y, Shibayama Y (2007) Preoperative evaluation of local invasion and metastatic lymph nodes of colorectal cancer and mesenteric vascular variations using multidetector-row computed tomography before laparoscopic surgery. J Comput Assist Tomogr 31(6):831–839. https://doi.org/10.1097/RCT.0b013e3180517af3
pubmed: 18043344
doi: 10.1097/RCT.0b013e3180517af3
de Vries FEE, da Costa DW, van der Mooren K, van Dorp TA, Vrouenraets BC (2014) The value of pre-operative computed tomography scanning for the assessment of lymph node status in patients with colon cancer. Eur J Surg Onc 12(40):1777–1781. https://doi.org/10.1016/j.ejso.2014.08.483
doi: 10.1016/j.ejso.2014.08.483
Rollvén E, Nordling A, Holm T, Blomqvist L (2017) Assessment and diagnostic accuracy of lymph node status to predict stage III colon cancer using computed tomography. Cancer Imaging. 19.17(1):3. https://doi.org/10.1186/s40644-016-0104-2
doi: 10.1186/s40644-016-0104-2
Kanehara-Shuppan (2009) Japanese Classification of Colorectal Carcinoma. Japanese Society for the Cancer of the Colon and Rectum, 2nd English ed. 815-824
Kanemitsu Y, Komori K, Kimura K, Kato T (2013) D3 Lymph node dissection in right hemicolectomy with a no-touch isolation technique in patients with colon cancer. Dis Colon Rectum 56(7):815–824. https://doi.org/10.1097/DCR.0b013e3182919093
pubmed: 23739187
doi: 10.1097/DCR.0b013e3182919093
Resch A, Langner C (2013) Lymph node staging in colorectal cancer: old controversies and recent advances. World J Gastroenterol 19(46):8515–8526. https://doi.org/10.3748/wjg.v19.i46.8515
pubmed: 24379568
pmcid: 3870496
doi: 10.3748/wjg.v19.i46.8515
Bertagnolli M, Miedema B, Redston M, Dowell J, Niedzwiecki D, Fleshman J, Bem J, Mayer R, Zinner M, Compton C (2004) Sentinel node staging of resectable colon cancer results of a multicenter study. Ann Surgery 240(4):624–628
Paramo JC, Summerall J, Poppiti R, Mesko TW (2002) Validation of sentinel node mapping in patients with colon cancer. Ann Surg Oncol. 9(6):550–554
pubmed: 12095970
doi: 10.1007/BF02573890
Bendavid Y, Latulippe JF, Younan RJ, Leclerc YE, Dube S, Heyen F, Morin M, Girard R, Bastien E, Ferreira J, Cerino M, Dubé P (2002) Phase I study on sentinel lymph node mapping in colon cancer: a preliminary report. J Surg Oncol 79(2):81–84
pubmed: 11815993
doi: 10.1002/jso.10052
Braat AE, Oosterhuis JW, Moll FC, de Vries JE, Wiggers T (2005) Sentinel node detection after preoperative short-course radiotherapy in rectal carcinoma is not reliable. Br J Surg. 92(12):1533–1538. https://doi.org/10.1002/bjs.5169
pubmed: 16231281
doi: 10.1002/bjs.5169
Hladík P, Vizd’a J, Hadzi Nikolov D, Dvorák J, Voboril Z (2005) Radio-guided sentinel node detection during the surgical treatment of rectal cancer. Nucl Med Commun. 26(11):977–982
pubmed: 16208175
doi: 10.1097/01.mnm.0000184997.35461.b8
Ivanov K, Kolev N, Ignatov V, Madjov R (2009) Intraoperative sentinel lymph node mapping in patients with colorectal cancer. Hepatogastroenterology. 56(89):99–105
pubmed: 19453037
Saha S, Sehgal R, Patel M, Doan K, Dan A, Bilchik A, Beutler T, Wiese D, Bassily N, Yee C (2006) A multicenter trial of sentinel lymph node mapping in colorectal cancer: prognostic implications for nodal staging and recurrence. Am J Surg. 191(3):305–310
pubmed: 16490536
doi: 10.1016/j.amjsurg.2005.10.028
Terwisscha Van Scheltinga S, Den Boer FC, Pijpers R, Meyer GA, Engel AF, Silvis R, Meijer S, van der Sijp JR (2006) Sentinel node staging in colon carcinoma: value of sentinel lymph node biopsy with radiocolloid and blue staining. Scand J Gastroenterol Suppl (243):153–157. https://doi.org/10.1080/00365520600664524
van der Zaag ES, Buskens CJ, Kooij N, Akol H, Peters HM, Bouma WH, Bemelman WA (2009) Improving staging accuracy in colon and rectal cancer by sentinel lymph node mapping: a comparative study. Eur J Surg Oncol. 35(10):1065–1070. https://doi.org/10.1016/j.ejso.2009.02.001
pubmed: 19261431
doi: 10.1016/j.ejso.2009.02.001
Emile SH, Elfeki H, Shalaby M, Sakr A, Sileri P, Laurberg S, Wexner S (2017) Sensitivity and specificity of indocyanine green near-infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: systematic review and meta-analysis. J Surg Oncol. 116(6):730–740. https://doi.org/10.1002/jso.24701
pubmed: 28570748
doi: 10.1002/jso.24701
Des Guetz G, Uzzan B, Nicolas P, Cucherat M, de Mestier P, Morere JF, Breau JL, Perret G (2007) Is sentinel lymph node mapping in colorectal cancer a future prognostic factor? A meta-analysis. World J Surg. 31(6):1304–1312. https://doi.org/10.1007/s00268-007-9012-8
pubmed: 17460811
doi: 10.1007/s00268-007-9012-8
Leufkens A, van den Bosch M, van Leeuwen M, Siersema P (2011) Diagnostic accuracy of computed tomography for colon cancer staging: a systematic review. Scand J Gastroenterol 46(7-8):887–894. https://doi.org/10.3109/00365521.2011.574732
pubmed: 21504379
doi: 10.3109/00365521.2011.574732
Dighe S, Purkayastha S, Swift I, Tekkis PP, Darzi A, A’Hern R, Brown G (2010) Diagnostic precision of CT in local staging of colon cancers: a meta-analysis. Clin Radiol. 65(9):708–719. https://doi.org/10.1016/j.crad.2010.01.024
pubmed: 20696298
doi: 10.1016/j.crad.2010.01.024
Cahill RA (2007) What’s wrong with sentinel node mapping in colon cancer? World J Gastroenterol 13(47):6291–6294
pubmed: 18081216
pmcid: 4205446
doi: 10.3748/wjg.v13.i47.6291
Cahill RA, Leroy J, Marescaux J (2008) Could lymphatic mapping and sentinel node biopsy provide oncological providence for local resectional techniques for colon cancer? A review of the literature. BMC Surg 8:17. https://doi.org/10.1186/1471-2482-8-17
pubmed: 18816403
pmcid: 2565653
doi: 10.1186/1471-2482-8-17
Bembenek AE, Rosenberg R, Wagler E, Gretschel S, Sendler A, Siewert JR, Nährig J, Witzigmann H, Hauss J, Knorr C, Dimmler A, Gröne J, Buhr HJ, Haier J, Herbst H, Tepel J, Siphos B, Kleespies A, Koenigsrainer A, Stoecklein NH, Horstmann O, Grützmann R, Imdahl A, Svoboda D, Wittekind C, Schneider W, Wernecke KD, Schlag PM (2007) Sentinel lymph node biopsy in colon cancer: a prospective multicenter trial. Ann Surg. 245(6):858–863. https://doi.org/10.1097/01.sla.0000250428.46656.7e
pubmed: 17522509
pmcid: 1876954
doi: 10.1097/01.sla.0000250428.46656.7e
Thomas KA, Lechner J, Shen P, Waters GS, Geisinger KR, Levine EA (2006) Use of sentinel node mapping for cancer of the colon: ‘to map or not to map’. Am Surg. 72(7):606–611
pubmed: 16875082
doi: 10.1177/000313480607200707
Tiffet O, Kaczmarek D, Chambonnière ML, Guillan T, Baccot S, Prévot N, Bageacu S, Bourgeois E, Cassagnau E, Lehur PA, Dubois F (2007) Combining radioisotopic and blue-dye technique does not improve the false-negative rate in sentinel lymph node mapping for colorectal cancer. Dis Colon Rectum. 50(7):962–970. https://doi.org/10.1007/s10350-007-0236-3
pubmed: 17468975
doi: 10.1007/s10350-007-0236-3
Ballardini B, Santoro L, Sangalli C, Gentilini O, Renne G, Lissidini G, Pagani GM, Toesca A, Blundo C, del Castillo A, Peradze N, Caldarella P, Veronesi P (2013) The indocyanine green method is equivalent to the
pubmed: 24184123
doi: 10.1016/j.ejso.2013.10.004
Nordgård O, Oltedal S, Kørner H, Aasprong OG, Tjensvoll K, Gilje B, Heikkilä R (2009) Quantitative RT-PCR detection of tumor cells in sentinel lymph nodes isolated from colon cancer patients with an ex vivo approach. Ann Surg. 249(4):602–607. https://doi.org/10.1097/SLA.0b013e31819ec923
pubmed: 19300229
doi: 10.1097/SLA.0b013e31819ec923