β-Asarone improves learning and memory in Aβ
Allylbenzene Derivatives
/ pharmacology
Alzheimer Disease
/ metabolism
Amyloid beta-Peptides
/ metabolism
Animals
Anisoles
/ pharmacology
Disease Models, Animal
Female
Hippocampus
/ drug effects
Learning
/ drug effects
Male
Maze Learning
/ drug effects
Memory
/ drug effects
Mitophagy
/ drug effects
Neurons
/ drug effects
Peptide Fragments
/ metabolism
Protein Kinases
/ metabolism
Rats
Rats, Wistar
Ubiquitin-Protein Ligases
/ metabolism
Alzheimer’s disease
Mitophagy
PINK1/Parkin
β-Asarone
Journal
Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
23
03
2020
accepted:
09
06
2020
pubmed:
20
6
2020
medline:
21
8
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a chronic neurodegenerative disease that is characterized by the extracellular accumulation of β-amyloid (Aβ). Many studies have shown a close relationship between autophagy and the formation of Aβ. As AD develops and progresses, mitophagy diminishes insoluble Aβ, and mitochondrial dysfunction seems to be a determining factor in the pathogenesis of AD. In our previous study, we showed that β-asarone pharmacological effects in APP/PS1 transgenic mice, reducing Aβ expression. However, the specific mechanism of this effect remains unclear. In this study, AD model rats induced by intracerebroventricular injection of Aβ
Identifiants
pubmed: 32556928
doi: 10.1007/s11011-020-00587-2
pii: 10.1007/s11011-020-00587-2
doi:
Substances chimiques
Allylbenzene Derivatives
0
Amyloid beta-Peptides
0
Anisoles
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
asarone
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
parkin protein
EC 2.3.2.27
Protein Kinases
EC 2.7.-
PTEN-induced putative kinase
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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