Placental transfer of pesticides studied in human placental perfusion.
BeWo cell model
bitertanol
cypermethrin
foetal exposure
pesticides
placental transport
propiconazole
Journal
Basic & clinical pharmacology & toxicology
ISSN: 1742-7843
Titre abrégé: Basic Clin Pharmacol Toxicol
Pays: England
ID NLM: 101208422
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
02
04
2020
revised:
10
06
2020
accepted:
10
06
2020
pubmed:
20
6
2020
medline:
3
8
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.
Identifiants
pubmed: 32558230
doi: 10.1111/bcpt.13456
pmc: PMC7689789
doi:
Substances chimiques
Biphenyl Compounds
0
Endocrine Disruptors
0
Pesticides
0
Pyrethrins
0
Triazoles
0
propiconazole
142KW8TBSR
cypermethrin
1TR49121NP
bitertanol
GR7Z3Z59G9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
505-515Subventions
Organisme : Miljøstyrelsen
Informations de copyright
© 2020 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
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