Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation.
CA1
calbindin
hippocampus
lissencephaly
microcircuitry
mouse
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
19 06 2020
19 06 2020
Historique:
received:
15
01
2020
accepted:
19
06
2020
pubmed:
20
6
2020
medline:
17
2
2021
entrez:
20
6
2020
Statut:
epublish
Résumé
Layering has been a long-appreciated feature of higher order mammalian brain structures but the extent to which it plays an instructive role in synaptic specification remains unknown. Here we examine the formation of synaptic circuitry under cellular heterotopia in hippocampal CA1, using a mouse model of the human neurodevelopmental disorder Type I Lissencephaly. We identify calbindin-expressing principal cells which are mispositioned under cellular heterotopia. Ectopic calbindin-expressing principal cells develop relatively normal morphological features and stunted intrinsic physiological features. Regarding network development, a connectivity preference for cholecystokinin-expressing interneurons to target calbindin-expressing principal cells is diminished. Moreover, in vitro gamma oscillatory activity is less synchronous across heterotopic bands and mutants are less responsive to pharmacological inhibition of cholecystokinin-containing interneurons. This study will aid not only in our understanding of how cellular networks form but highlight vulnerable cellular circuit motifs that might be generalized across disease states.
Identifiants
pubmed: 32558643
doi: 10.7554/eLife.55173
pii: 55173
pmc: PMC7340499
doi:
pii:
Substances chimiques
Calbindins
0
Cholecystokinin
9011-97-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : FI2 GM123992
Pays : United States
Déclaration de conflit d'intérêts
JD, TE, SG, XY, CM No competing interests declared
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