Development of a novel glycated protein-based fibrosis prediction score for determination of significant liver fibrosis in HCV-infected patients, a preliminary study.
chronic hepatitis C
fibrosis prediction score
glycated albumin
liver fibrosis
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
04
02
2020
accepted:
14
06
2020
medline:
20
6
2020
pubmed:
20
6
2020
entrez:
20
6
2020
Statut:
ppublish
Résumé
The current study aimed to investigate the diagnostic value of glycated albumin (GA), glycated hemoglobin (HbA1c), and a number of routine biomarkers as noninvasive indicators of liver fibrosis in patients with chronic hepatitis C (CHC). One hundred patients with CHC were subjected to full medical history and examination, in addition to ultrasound-guided liver biopsy and histopathological examination for assessment of liver fibrosis stage. GA and HbA1c values, GA/HbA1c ratio, liver function tests, complete blood count, and alpha fetoprotein (AFP) were determined. A novel noninvasive index, dubbed Fibrosis Prediction Score (FPS), was selected for predicting significant liver fibrosis based on total bilirubin, glycated albumin, platelet count, age, and AFP. A validation study for FPS was applied on archival data which include 66 diabetics' patients. The FPS had area under the curve (AUC) of 0.92 for classification of patients with significant fibrosis with 81% sensitivity and 95% specificity. The AUCs of FPS in predicting advanced fibrosis and cirrhosis were 0.86 and 0.82, respectively. Comparison of AST-to-platelet ratio index (APRI) and FIB-4 with FPS indicated increased sensitivity and specificity of FPS over APRI and FIB4 in both significant and advanced fibrosis. FPS has a good sensitivity and specificity for prediction of significant and advanced liver fibrosis in patients with CHC.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3525-3533Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Sebastiani G, Gkouvatsos K, Pantopoulos K. Chronic hepatitis C and liver fibrosis. World J Gastroenterol. 2014;20(32):110.
El-Zanaty F, Way A. Demographic and Health Survey 2008. Cairo, Egypt: Ministry of Health, El-Zanaty and Associates, and Macro International; 2009:431.
Ciesek S, Steinmann E, Helfritz FA, et al. Glucocorticosteroids increase cell entry by hepatitis C virus. J Hepatol. 2010;138(5):1875-1884.
Jacobson IM, Cacoub P, Dal Maso L, Harrison SA, Younossi ZM. Manifestations of chronic hepatitis C virus infection beyond the liver. Clin Gastroenterol Hepatol. 2010;8(12):1017-1029.
West J, Card TR. Reduced mortality rates following elective percutaneous liver biopsies. Gastroenterology. 2010;139:1230-1237.
Bedossa P, Carrat F. Liver biopsy: the best, not the gold standard. J Hepatol. 2009;50:1-3.
Martinez SM, Crespo G, Navasa M, Fornes X. Noninvasive assessment of liver fibrosis. Hepatol. 2011;53:325-335.
Berzigotti A, Abraldes JG, Tandon P. Ultrasonographic evaluation of liver surface and transient elastography in clinically doubtful cirrhosis. J Hepatol. 2010;52:846-853.
Zarski JP, Sturm N, Guechot J. Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study. J Hepatol. 2012;56:55-62.
Enomoto H, Aizawa N, Nakamura H, et al. A new metabolism-related index correlates with the degree of liver fibrosis in hepatitis C virus-positive patients. Gastroenterol Res Pract. 2015:926169. https://doi.org/10.1155/2015/926169
Bando Y, Kanehara H, Toya D, Tanaka N, Kasayama S, Koga M. Association of serum glycated albumin to heamoglobinA1C ratio with hepatic function tests in patients with chronic liver disease. Ann Clin Biochem. 2009;46(5):368-372.
Bando Y, Kanehara H, Toya D, et al. The glycated albumin to glycated heamoglobin ratio increases along with the fibrosis stage in non-alcoholic steatohepatitis. Ann Clin Biochem. 2012;49:387-390.
Bedossa P, Bioulac-Sage P, Callard P, et al. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. J Hepatology. 1994;20(1):15-20.
Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Fontaine H, Pol S. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. Hepatology. 2007;46(1):32-36.
Wai CT, Greenson JK, Fontana RJ. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38(2):518-526.
Chang TT, Liaw YF, Wu SS. Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B. Hepatology. 2010;52:886-893.
Jarcuska P, Janicko M, Veseliny E, Jarcuska P, Skladany L. Circulating markers of liver fibrosis progression. Clin Chim Acta. 2010;411(15-16):1009-1017.
Ratziu V. Serum fibrosis markers: death by validation or a leap of faith? J Hepatol. 2010;53:222-224.
Cassinotto C, Lapuyade B, Mouries A. Non-invasive assessment of liver fibrosis with impulse elastography: comparison of supersonic shear imaging with ARFI and FibroScan. J Hepatol. 2014;61(3):550-557.
European Association for Study of Liver. EASL. Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol. 2014;60(2):392-420.
Myers RP, De Torres M, Imbert-Bismut F, Ratziu V, Charlotte F, Poynard T. Biochemical markers of fibrosis in patients with chronic hepatitis C: a comparison with prothrombin time, platelet count, and age-platelet index. Dig Dis Sci. 2003;48(1):146-153.
Ryder SD, Irving WL, Jones DA, Neal KR, Underwood JC. Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study. Gut. 2004;53:451-455.
Derbala M, Elbadri ME, Amer AM, et al. Aspartate transaminase to platelet ratio index in hepatitis C virus and Schistosomiasis coinfection. World J Gastroenterol. 2015;21(46):13132-13139.
Zechini B, Pasquazzi C, Aceti A. Correlation of serum aminotransferases with HCV RNA levels and histological findings in patients with chronic hepatitis C: the role of serum aspartate transaminase in the evaluation of disease progression. Eur J Gastroenterol Hepatol. 2004;16(9):891-896.
Shahid M, Idrees M, Nasir B, et al. Correlation of biochemical markers and HCV RNA titers with fibrosis stages and grades in chronic HCV-3a patients. Eur J Gastroenterol Hepatol. 2014;26(7):788-794.
Kobeisy MA, Morsy KH, Galal M, Sayed SK, Ashmawy MM, Mohammad FM. Clinical significance of elevated alpha-foetoprotein (AFP) in patients with chronic hepatitis C without hepatocellular carcinoma in Upper Egypt. Arab J Gastroenterol. 2012;13(2):49-53.
Attallah AM, Abdallah SO, Attallah AA, et al. Diagnostic value of fibronectin discriminant score for predicting liver fibrosis stages in chronic hepatitis C virus patients. Ann Hepatol. 2013;12(1):44-5344.
Huang Z, Chen X, Zhao Q, et al. An albumin, collagen IV, and longitudinal diameter of spleen scoring system superior to APRI for assessing liver fibrosis in chronic hepatitis B patients. Int J Infect Dis. 2015;31:18-22.
Attallah AM, El-Far M, Abdel Malak CA, et al. Fibro-check: a combination of direct and indirect markers for liver fibrosis staging in chronic hepatitis C patients. Ann Hepatol. 2015;14(2):225-233.
Clarke M, Benmoussa J, Penmetsa A, Otterbec Pk, Ebrahim F, Nfonoyim J. Inaccuracies of hemoglobin A1c in liver cirrhosis: a case report. J Endocrinol Metab. 2016;6(1):30-32. https://doi.org/10.14740/jem326w
Isoda H, Takahashi H, Eguchi Y, et al. Re-evaluation of glycated hemoglobin and glycated albumin with continuous glucose monitoring system as markers of glycemia in patients with liver cirrhosis. Biomed Rep. 2017;6(1):51-56. https://doi.org/10.3892/br.2016.808
Aizawa N, Enomoto H, Imanishi H, et al. Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of HCV-related liver fibrosis. World. J Hepatol. 2012;4(1):11-17.
Enomoto H, Aizawa N, Nakamura H, et al. An increased ratio of glycated albumin to HbA1c is associated with the degree of liver fibrosis in hepatitis B virus-positive patients. Gastroenterol Res Pract. 2014;8:351396. https://doi.org/10.1155/2014/351396