Nasopharyngeal Epstein-Barr virus DNA loads in high-risk nasopharyngeal carcinoma families: Familial aggregation and host heritability.
Epstein-Barr virus
familial aggregation
genetics
heritability
high-risk family
nasopharyngeal carcinoma
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
22
05
2020
accepted:
16
06
2020
medline:
20
6
2020
pubmed:
20
6
2020
entrez:
20
6
2020
Statut:
ppublish
Résumé
Nasopharyngeal carcinoma (NPC), the most common head and neck cancer, is characterized by distinct geographic distribution and familial aggregation. Multiple risk factors, including host genetics, environmental factor, and EBV infection, have been linked to the development of NPC, particularly in the familial clustering cases. However, the cause of NPC endemicity remains enigmatic due possibly to the complicated interplay between these risk factors. Recently, positive Epstein-Barr virus (EBV) DNA loads at nasopharyngeal (NP) cavity has been found to reflect NPC development and applied in NPC screening. To examine whether the increased NP EBV loads could aggregate in the families and be affected by host genetics and environmental factor, EBV loads were obtained by 510 NP brushing samples from eligible unaffected individuals, who have two or more relatives affected with NPC, in 116 high-risk NPC families. The correlation of relative pairs was estimated using S.A.G.E. (version 6.4, 2016), and host heritability of NP EBV loads was calculated with variance component models using SOLAR (version 8.4.2, 2019). In result, significant correlations of EBV loads were observed between parent-offspring pairs and sibling-sibling pairs (P < .001), but not in distant kin relationship pairs. Interestingly, after excluding the shared environmental factor within families, host genetics contributes significantly to NP EBV loads with a heritability of 56.41% (P = 1.00 × 10
Identifiants
pubmed: 32558959
doi: 10.1002/jmv.26198
pmc: PMC7689818
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3717-3725Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB015611
Pays : United States
Informations de copyright
© 2020 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
Références
Tang LL, Chen WQ, Xue WQ, et al. Global trends in incidence and mortality of nasopharyngeal carcinoma. Cancer Lett. 2016;374(1):22-30.
Jia WH, Feng BJ, Xu ZL, et al. Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China. Cancer. 2004;101(2):363-369.
Liu Z, Chang ET, Liu Q, et al. Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area. Cancer. 2017;123(14):2716-2725.
Dai J, Shen W, Wen W, et al. Estimation of heritability for nine common cancers using data from genome-wide association studies in Chinese population. Int J Cancer. 2017;140(2):329-336.
Yu G, Hsu WL, Coghill AE, et al. Whole-exome sequencing of nasopharyngeal carcinoma families reveals novel variants potentially involved in nasopharyngeal carcinoma. Sci Rep. 2019;9(1):9916.
Welcsh PL, Owens KN, King MC. Insights into the functions of BRCA1 and BRCA2. Trends Genet. 2000;16(2):69-74.
Mahdavi M, Nassiri M, Kooshyar MM, et al. Hereditary breast cancer; genetic penetrance and current status with BRCA. J Cell Physiol. 2019;234(5):5741-5750.
Lu SJ, Day NE, Degos L, et al. Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature. 1990;346(6283):470-471.
Su WH, Hildesheim A, Chang YS. Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers. Front Oncol. 2013;3:299.
Ramayanti O, Juwana H, Verkuijlen SA, et al. Epstein-Barr virus mRNA profiles and viral DNA methylation status in nasopharyngeal brushings from nasopharyngeal carcinoma patients reflect tumor origin. Int J Cancer. 2017;140(1):149-162.
Tsao SW, Tsang CM, Lo KW. Epstein-Barr virus infection and nasopharyngeal carcinoma. Philos Trans R Soc Lond B Biol Sci. 2017;372(1732).
Chien YC, Chen JY, Liu MY, et al. Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. New Engl J Med. 2001;345(26):1877-1882.
Zeng Y, Zhang LG, Wu YC, et al. Prospective studies on nasopharyngeal carcinoma in Epstein-Barr virus IgA/VCA antibody-positive persons in Wuzhou City, China. Int J Cancer. 1985;36(5):545-547.
Chen Y, Zhao W, Lin L, et al. Nasopharyngeal Epstein-Barr virus load: an efficient supplementary method for population-based nasopharyngeal carcinoma screening. PLoS One. 2015;10(7):e0132669.
Zheng XH, Lu LX, Li XZ, Jia WH. Quantification of Epstein-Barr virus DNA load in nasopharyngeal brushing samples in the diagnosis of nasopharyngeal carcinoma in southern China. Cancer Sci. 2015;106(9):1196-1201.
He YQ, Liao XY, Xue WQ, et al. Association between environmental factors and oral Epstein-Barr virus dna loads: a multicenter cross-sectional study in China. J Infect Dis. 2019;219(3):400-409.
Xue WQ, He YQ, Liao XY, et al. Decreased oral Epstein-Barr virus DNA loads in patients with nasopharyngeal carcinoma in southern China: a case-control and a family-based study. Cancer Med. 2018;7:3453-3464.
Lo YM, Chan LY, Lo KW, et al. Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res. 1999;59(6):1188-1191.
Zhou X, Stephens M. Genome-wide efficient mixed-model analysis for association studies. Nat Genet. 2012;44(7):821-824.
Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet. 1998;62(5):1198-1211.
Qin HD, Jia WH, Zhang LL, et al. Elevated Epstein-Barr virus seroreactivity among unaffected members of families with nasopharyngeal carcinoma. J Med Virol. 2011;83(10):1792-1798.
Mathias RA, Deepa M, Deepa R, Wilson AF, Mohan V. Heritability of quantitative traits associated with type 2 diabetes mellitus in large multiplex families from South India. Metab: Clin Exp. 2009;58(10):1439-1455.
Souto JC, Pena G, Ziyatdinov A, et al. A genomewide study of body mass index and its genetic correlation with thromboembolic risk. Results from the GAIT project. Thromb Haemost. 2014;112(5):1036-1043.
Kim Y, Lee Y, Lee S, et al. On the estimation of heritability with family-based and population-based samples. BioMed Res Int. 2015;2015:671349.
Stevens SJ, Verkuijlen SA, Hariwiyanto B, et al. Noninvasive diagnosis of nasopharyngeal carcinoma: nasopharyngeal brushings reveal high Epstein-Barr virus DNA load and carcinoma-specific viral BARF1 mRNA. Int J Cancer. 2006;119(3):608-614.
Zheng X-H, Wang R-Z, Li X-Z, et al. Detection of methylation status of Epstein-Barr virus DNA C promoter in the diagnosis of nasopharyngeal carcinoma. Cancer Sci. 2020;111(2):592-600.
Song Y, Schwager MJ, Backer V, et al. Environment changes genetic effects on respiratory conditions and allergic phenotypes. Sci Rep. 2017;7(1):6342.
Renner B, Mueller CA, Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflammation Res. 2012;61(10):1041-1052.
Graham JP, Corella Barud V, Avitia Diaz R, Gurian P. The in-home environment and household health: a cross-sectional study of informal urban settlements in northern Mexico. Int J Env Res Public Health. 2005;2(3-4):394-402.
Besson C, Amiel C, Le-Pendeven C, et al. Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas. J Infect Dis. 2009;199(8):1121-1127.
Tse KP, Su WH, Chang KP, et al. Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. Am J Hum Genet. 2009;85(2):194-203.
Bei JX, Li Y, Jia WH, et al. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet. 2010;42(7):599-603.
Ruan HL, Qin HD, Shugart YY, et al. Developing genetic epidemiological models to predict risk for nasopharyngeal carcinoma in high-risk population of China. PLoS One. 2013;8(2):e56128.
Bei J-X, Su W-H, Ng C-C, et al. A GWAS meta-analysis and replication study identifies a novel locus within CLPTM1L/TERT associated with nasopharyngeal carcinoma in individuals of Chinese ancestry. Cancer Epidemiol Biomark Prev. 2016;25(1):188-192.