Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation.
cellular signaling
electron holography
magnetic nanoparticles
magnetic vortex
mechanosensitive ion channels
mechanotransduction
neuromodulation
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
28 07 2020
28 07 2020
Historique:
pubmed:
20
6
2020
medline:
15
5
2021
entrez:
20
6
2020
Statut:
ppublish
Résumé
Magnetic nanomaterials in magnetic fields can serve as versatile transducers for remote interrogation of cell functions. In this study, we leveraged the transition from vortex to in-plane magnetization in iron oxide nanodiscs to modulate the activity of mechanosensory cells. When a vortex configuration of spins is present in magnetic nanomaterials, it enables rapid control over their magnetization direction and magnitude. The vortex configuration manifests in near zero net magnetic moment in the absence of a magnetic field, affording greater colloidal stability of magnetic nanomaterials in suspensions. Together, these properties invite the application of magnetic vortex particles as transducers of externally applied minimally invasive magnetic stimuli in biological systems. Using magnetic modeling and electron holography, we predict and experimentally demonstrate magnetic vortex states in an array of colloidally synthesized magnetite nanodiscs 98-226 nm in diameter. The magnetic nanodiscs applied as transducers of torque for remote control of mechanosensory neurons demonstrated the ability to trigger Ca
Identifiants
pubmed: 32559057
doi: 10.1021/acsnano.0c00562
pmc: PMC8592276
mid: NIHMS1750035
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
8036-8045Subventions
Organisme : NIMH NIH HHS
ID : R01 MH111872
Pays : United States
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