Cannabis extract for the treatment of painful tonic spasms in a patient with neuromyelitis optica spectrum disorder: A case report.

Aquaporin 4 Cannabis Humans Myelitis, Transverse Neuromyelitis Optica / complications Plant Extracts / therapeutic use Spasm / complications
Cannabis Carbamazepine Longitudinally extensive transverse myelitis Neuromyelitis optica (NMO) Painful tonic spasm THC

Journal

Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 16 04 2020
revised: 27 05 2020
accepted: 07 06 2020
pubmed: 20 6 2020
medline: 15 5 2021
entrez: 20 6 2020
Statut: ppublish

Résumé

Painful tonic spasm (PTS) is a common yet debilitating symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), especially those with longitudinally extensive transverse myelitis. Although carbamazepine is an effective treatment, it poses the risk of severe adverse reactions, such as Steven-Johnson syndrome (SJS). In this case report, we describe an NMOSD patient with severe PTS suffering from carbamazepine-induced SJS who responded well to cannabis extract. Since cannabinoids can ameliorate spasticity in an experimental autoimmune encephalomyelitis model through cannabinoid 1 (CB1) receptor activation, cannabis extract which includes delta-9-tetrahydrocannabinol (THC) is a potential treatment option for PTS in NMOSD patients.

Identifiants

DOI: 10.1016/j.msard.2020.102278 PMID: 32559701
pubmed: 32559701
pii: S2211-0348(20)30354-0
doi: 10.1016/j.msard.2020.102278
pii:
doi:

Substances chimiques

Aquaporin 4 0
Plant Extracts 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102278

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Nanthaya Tisavipat (N)

Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand. Electronic address: nanthaya90@gmail.com.

Sasitorn Siritho (S)

Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Siriraj Neuroimmunology Center, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Bumrungrad International Hospital, Bangkok, 10110, Thailand. Electronic address: siritho@yahoo.com.

Naraporn Prayoonwiwat (N)

Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Siriraj Neuroimmunology Center, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand. Electronic address: naraporn.pra@mahidol.ac.th.

Jiraporn Jitprapaikulsan (J)

Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand; Siriraj Neuroimmunology Center, Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, 10700, Thailand. Electronic address: jiraporn.jit@mahidol.ac.th.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Porines › Aquaporines › Aquaporine-4 › Cannabis extract for the treatment of painful...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Rosales › Cannabaceae › Cannabis › Cannabis extract for the treatment of painful...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cannabis extract for the treatment of painful...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Myélite transverse › Cannabis extract for the treatment of painful...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Neuromyélite optique › Cannabis extract for the treatment of painful...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Cannabis extract for the treatment of painful...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Spasme › Cannabis extract for the treatment of painful...