Origin and Lineage Plasticity of Endogenous Lacrimal Gland Epithelial Stem/Progenitor Cells.
Biological Sciences
Cell Biology
Developmental Biology
Stem Cells Research
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
26 Jun 2020
26 Jun 2020
Historique:
received:
04
12
2019
revised:
03
04
2020
accepted:
29
05
2020
pubmed:
20
6
2020
medline:
20
6
2020
entrez:
20
6
2020
Statut:
ppublish
Résumé
The lacrimal gland (LG) is an exocrine organ responsible for the secretion of aqueous tear film. Regenerative and stem cell therapies that target LG repair are coming to the fore, although our understanding of LG cell lineage hierarchy is still incomplete. We utilize the analysis of label-retaining cells (LRCs) and genetic lineage tracing to define LG cell lineage hierarchy. Our study suggests that embryonic LG contains unique long-lived multipotent stem cells that give rise to all postnatal epithelial cell types. Following birth, lineages become established and the fate of progenitor cell descendants becomes restricted. However, some cell lineages retain plasticity after maturation and can trans-differentiate into other cell types upon injury. The demonstration that the LG contains progenitor cells with different levels of plasticity has profound implications for our understanding of LG gland function in homeostasis and disease and will be helpful for developing stem cell-based therapies in the future.
Identifiants
pubmed: 32559730
pii: S2589-0042(20)30415-6
doi: 10.1016/j.isci.2020.101230
pmc: PMC7303985
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101230Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR055607
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026202
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028983
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
Sci Signal. 2009 Sep 15;2(88):ra55
pubmed: 19755711
Dev Cell. 2015 Apr 20;33(2):231-7
pubmed: 25843887
Dev Dyn. 2017 Dec;246(12):970-980
pubmed: 28710815
Genes Dev. 2016 Jun 1;30(11):1261-77
pubmed: 27284162
Stem Cells Transl Med. 2017 Jan;6(1):88-98
pubmed: 28170196
J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):211-9
pubmed: 16807801
J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):261-72
pubmed: 16807805
Optom Vis Sci. 2009 Nov;86(11):1235-40
pubmed: 19770810
Sci Rep. 2018 Jul 2;8(1):9919
pubmed: 29967327
Exp Eye Res. 2016 Dec;153:27-41
pubmed: 27697548
Radiother Oncol. 2009 Sep;92(3):466-71
pubmed: 19625095
Invest Ophthalmol Vis Sci. 2012 May 14;53(6):2749-59
pubmed: 22427571
Ocul Surf. 2018 Oct;16(4):470-477
pubmed: 30055331
Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4399-406
pubmed: 18586880
Nature. 2014 Feb 20;506(7488):322-7
pubmed: 24463516
Hum Pathol. 1982 Mar;13(3):236-62
pubmed: 6281165
Cell Stem Cell. 2018 May 3;22(5):668-683.e6
pubmed: 29656943
Am J Respir Cell Mol Biol. 2017 Jun;56(6):716-726
pubmed: 28125268
Front Physiol. 2017 Sep 26;8:739
pubmed: 29033846
Curr Mol Biol Rep. 2015 Sep 1;1(3):115-123
pubmed: 26688786
Kurume Med J. 1981;28(2):103-12
pubmed: 7329029
Prog Retin Eye Res. 2009 May;28(3):155-77
pubmed: 19376264
Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7338-44
pubmed: 26559480
Diagn Cytopathol. 2012 Mar;40(3):220-7
pubmed: 20891000
Nat Commun. 2013;4:2497
pubmed: 24084941
PLoS One. 2014 Sep 19;9(9):e107893
pubmed: 25238060
Genes Dev. 2014 Jun 1;28(11):1143-58
pubmed: 24888586
Development. 2017 Jul 1;144(13):2517-2528
pubmed: 28576768
Nat Cell Biol. 2018 Jun;20(6):666-676
pubmed: 29784918
Cell Tissue Res. 2011 Dec;346(3):317-26
pubmed: 22101331
Genesis. 2018 May;56(5):e23211
pubmed: 29663717
Development. 2014 Jul;141(13):2691-701
pubmed: 24924191
Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5654-5665
pubmed: 29098296
Invest Ophthalmol Vis Sci. 2013 May 01;54(5):3115-25
pubmed: 23532528
PLoS One. 2013 Sep 18;8(9):e74174
pubmed: 24058524
Stem Cells. 2014 Aug;32(8):2267-77
pubmed: 24715701
Cell Stem Cell. 2018 May 3;22(5):779
pubmed: 29727685
Nat Cell Biol. 2014 Oct;16(10):942-50, 1-7
pubmed: 25173976
Cornea. 2007 Aug;26(7):805-9
pubmed: 17667613
Cell Rep. 2017 Aug 15;20(7):1525-1532
pubmed: 28813665
Dev Biol. 2000 Sep 1;225(1):188-200
pubmed: 10964474
Nature. 2006 Jan 5;439(7072):84-8
pubmed: 16397499
Front Genet. 2019 May 28;10:362
pubmed: 31191595
Development. 2000 Jun;127(12):2563-72
pubmed: 10821755
J Histochem Cytochem. 2009 Feb;57(2):177-85
pubmed: 19001638
Adv Exp Med Biol. 2002;506(Pt B):1283-4
pubmed: 12614068
Crit Rev Clin Lab Sci. 1987;25(2):161-93
pubmed: 3301214
Histol Histopathol. 1995 Oct;10(4):821-7
pubmed: 8574002
Exp Eye Res. 2006 May;82(5):885-98
pubmed: 16309672
Home Healthc Now. 2018 Mar/Apr;36(2):74-83
pubmed: 29498987
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Dec;82(6):674-80
pubmed: 8974141
J Cell Sci. 1999 Jun;112 ( Pt 12):1925-36
pubmed: 10341211