pH-Responsive Resveratrol-Loaded Electrospun Membranes for the Prevention of Implant-Associated Infections.
antibiofilm
bioresorbable membrane
electrospinning
phytochemicals
polylactic acid
resveratrol
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
16 Jun 2020
16 Jun 2020
Historique:
received:
07
05
2020
revised:
10
06
2020
accepted:
12
06
2020
entrez:
21
6
2020
pubmed:
21
6
2020
medline:
21
6
2020
Statut:
epublish
Résumé
To date, the implant-associated infections represent a worldwide challenge for the recently reported bacterial drug resistance that can lead to the inefficacy or low efficacy of conventional antibiotic therapies. Plant polyphenolic compounds, including resveratrol (RSV), are increasingly gaining consensus as valid and effective alternatives to antibiotics limiting antibiotic resistance. In this study, electrospun polylactic acid (PLA) membranes loaded with different concentrations of RSV are synthesized and characterized in their chemical, morphological, and release features. The obtained data show that the RSV release rate from the PLA-membranes is remarkably higher in acidic conditions than at neutral pH. In addition, a change in pH from neutral to slightly acidic triggers a significant increase in the RSV release. This behavior indicates that the PLA-RSV membranes can act as drug reservoir when the environmental pH is neutral, starting to release the bioactive molecules when the pH decreases, as in presence of oral bacterial infection. Indeed, our results demonstrate that PLA-RSV2 displays a significant antibacterial and antibiofilm activity against two bacterial strains,
Identifiants
pubmed: 32560209
pii: nano10061175
doi: 10.3390/nano10061175
pmc: PMC7353298
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Regione Campania
ID : PON 03 PE_00110_1/ptd1_000410
Organisme : Regione Campania
ID : B93D18000350007
Organisme : Horizon 2020
ID : 734759
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