Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model.
ionizing radiation
lipidomics
mass spectrometry
oxygen radiation
plasma metabolomics
untargeted profiling
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
17 Jun 2020
17 Jun 2020
Historique:
received:
12
05
2020
revised:
09
06
2020
accepted:
12
06
2020
entrez:
21
6
2020
pubmed:
21
6
2020
medline:
21
6
2020
Statut:
epublish
Résumé
Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (
Identifiants
pubmed: 32560360
pii: metabo10060252
doi: 10.3390/metabo10060252
pmc: PMC7345467
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NASA
ID : 80NSSC17K0425
Pays : United States
Organisme : NASA
ID : 80NSSC19K0437
Pays : United States
Organisme : National Space Biomedical Research Institute
ID : NCC 9-58
Organisme : NIH/NCI/CCSG
ID : P30-CA051008
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