Does time taken by paediatric critical care transport teams to reach the bedside of critically ill children affect survival? A retrospective cohort study from England and Wales.


Journal

BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804

Informations de publication

Date de publication:
19 06 2020
Historique:
received: 21 04 2020
accepted: 05 06 2020
entrez: 21 6 2020
pubmed: 21 6 2020
medline: 15 5 2021
Statut: epublish

Résumé

Reaching the bedside of a critically ill child within three hours of agreeing the child requires intensive care is a key target for Paediatric Critical Care Transport teams (PCCTs) to achieve in the United Kingdom. Whilst timely access to specialist care is necessary for these children, it is unknown to what extent time taken for the PCCT to arrive at the bedside affects clinical outcome. Data from transports of critically ill children who were admitted to Paediatric Intensive Care Units (PICUs) in England and Wales from 1 January 2014 to 31 December 2016 were extracted from the Paediatric Intensive Care Audit Network (PICANet) and linked with adult critical care data and Office for National Statistics mortality data. Logistic regression models, adjusted for pre-specified confounders, were fitted to investigate the impact of time-to-bedside on mortality within 30 days of admission and other key time points. Negative binomial models were used to investigate the impact of time-to-bedside on PICU length of stay and duration of invasive ventilation. There were 9116 children transported during the study period, and 645 (7.1%) died within 30 days of PICU admission. There was no evidence that 30-day mortality changed as time-to-bedside increased. A similar relationship was seen for mortality at other pre-selected time points. In children who waited longer for a team to arrive, there was limited evidence of a small increase in PICU length of stay (expected number of days increased from: 7.17 to 7.58). There is no evidence that reducing the time-to-bedside target for PCCTs will improve the survival of critically ill children. A shorter time to bedside may be associated with a small reduction in PICU length of stay.

Sections du résumé

BACKGROUND
Reaching the bedside of a critically ill child within three hours of agreeing the child requires intensive care is a key target for Paediatric Critical Care Transport teams (PCCTs) to achieve in the United Kingdom. Whilst timely access to specialist care is necessary for these children, it is unknown to what extent time taken for the PCCT to arrive at the bedside affects clinical outcome.
METHODS
Data from transports of critically ill children who were admitted to Paediatric Intensive Care Units (PICUs) in England and Wales from 1 January 2014 to 31 December 2016 were extracted from the Paediatric Intensive Care Audit Network (PICANet) and linked with adult critical care data and Office for National Statistics mortality data. Logistic regression models, adjusted for pre-specified confounders, were fitted to investigate the impact of time-to-bedside on mortality within 30 days of admission and other key time points. Negative binomial models were used to investigate the impact of time-to-bedside on PICU length of stay and duration of invasive ventilation.
RESULTS
There were 9116 children transported during the study period, and 645 (7.1%) died within 30 days of PICU admission. There was no evidence that 30-day mortality changed as time-to-bedside increased. A similar relationship was seen for mortality at other pre-selected time points. In children who waited longer for a team to arrive, there was limited evidence of a small increase in PICU length of stay (expected number of days increased from: 7.17 to 7.58).
CONCLUSION
There is no evidence that reducing the time-to-bedside target for PCCTs will improve the survival of critically ill children. A shorter time to bedside may be associated with a small reduction in PICU length of stay.

Identifiants

pubmed: 32560633
doi: 10.1186/s12887-020-02195-6
pii: 10.1186/s12887-020-02195-6
pmc: PMC7304220
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

301

Subventions

Organisme : Department of Health
ID : 15/136/45
Pays : United Kingdom
Organisme : Health Services Research Programme
ID : 15/136/45
Pays : International

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Auteurs

Sarah E Seaton (SE)

Department of Health Sciences, University of Leicester, University Road, Leicester, UK.

Padmanabhan Ramnarayan (P)

Children's Acute Transport Service (CATS), Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Respiratory, Critical Care and Anaesthesia Section, Infection, Immunity and Inflammation Research & Teaching Department, UCL GOS Institute of Child Health, London, UK.

Patrick Davies (P)

Nottingham University Hospital NHS Trust, Nottingham, UK.

Emma Hudson (E)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Stephen Morris (S)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Christina Pagel (C)

Clinical Operational Research Unit, University College London, London, UK.

Fatemah Rajah (F)

Yorkshire and Humber Infant and Children's Transport Service (Embrace), Barnsley, UK.

Jo Wray (J)

Heart and Lung Directorate, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Elizabeth S Draper (ES)

Department of Health Sciences, University of Leicester, University Road, Leicester, UK. msn@le.ac.uk.

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