Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology.
Adolescent
Adult
Astigmatism
/ diagnosis
Child
Corneal Topography
Epithelium, Corneal
/ pathology
Female
Follow-Up Studies
Humans
Male
Myopia
/ physiopathology
Orthokeratologic Procedures
/ methods
Prospective Studies
Refraction, Ocular
/ physiology
Tomography, Optical Coherence
Visual Acuity
Young Adult
Corneal epithelium
Fourier-domain optical coherence tomography
Orthokeratology
Toricity
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
19 Jun 2020
19 Jun 2020
Historique:
received:
24
09
2019
accepted:
20
05
2020
entrez:
21
6
2020
pubmed:
21
6
2020
medline:
15
4
2021
Statut:
epublish
Résumé
The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear. This is a prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6 mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared. Visual acuity and refraction improved significantly after OK lens wear. △ETFm thinned more than △ETSm (P = 0.027) at 1.5 mm in radius. △ETSm thickened more than △ETFm at 2.5 mm (P = 0.019) and 3.0 mm (P = 0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0 mm, 2.5 mm and 3.0 mm. ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5 mm. Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear.
METHODS
METHODS
This is a prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of corneal toricity wore spherical OK lenses for 6 months. Evaluations of OK lens fit, visual acuity, refractions and corneal toricity (CT) were performed. Fourier-domain optical coherence tomography (FD-OCT) was conducted to measure the corneal epithelial thickness (ET) along the principle meridians of corneal toricity over a diameter of 6 mm. The means of △ET of the same diameter at individual meridians (△ETSm and △ETFm) were calculated and compared.
RESULTS
RESULTS
Visual acuity and refraction improved significantly after OK lens wear. △ETFm thinned more than △ETSm (P = 0.027) at 1.5 mm in radius. △ETSm thickened more than △ETFm at 2.5 mm (P = 0.019) and 3.0 mm (P = 0.036).∣△ETSm - △ETFm∣ were significantly correlated with the baseline central CT at 2.0 mm, 2.5 mm and 3.0 mm. ∣△ETSm - △ETFm∣was significantly correlated with the baseline peripheral CT at 2.5 mm.
CONCLUSIONS
CONCLUSIONS
Overnight wear of spherical OK lenses resulted in differential changes in the thickness profiles of the corneal epithelium between the steep and flat meridians in eyes with corneal toricity.
Identifiants
pubmed: 32560640
doi: 10.1186/s12886-020-01477-y
pii: 10.1186/s12886-020-01477-y
pmc: PMC7304131
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
240Commentaires et corrections
Type : ErratumIn
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