Imaging and biodistribution of radiolabeled SP90 peptide in BT-483 tumor bearing mice.

Animals Breast Neoplasms / diagnosis Cell Line, Tumor Female Gallium Radioisotopes / pharmacokinetics Heterocyclic Compounds, 1-Ring / metabolism Humans Indium Radioisotopes / pharmacokinetics Mice Mice, Inbred NOD Mice, SCID Multimodal Imaging Oligopeptides / chemistry Radiopharmaceuticals / chemistry Tissue Distribution Xenograft Model Antitumor Assays
BT-483 DOTA-SP90 nanoPET/CT nanoSPECT/CT

Journal

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 24 05 2019
revised: 22 03 2020
accepted: 27 03 2020
entrez: 21 6 2020
pubmed: 21 6 2020
medline: 8 7 2021
Statut: ppublish

Résumé

The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had significant binding affinity to BT-483 cancer cells. Biodistribution, nanoSPECT/CT and nanoPET/CT imaging results indicated that radiolabeled DOTA-SP90 can accumulate in tumors. In addition, radiolabeled DOTA-SP90 peptides can also detect metastatic tumors. Therefore, radiolabeled SP90 peptide may provide the potential capability as diagnostic agent for breast cancer patients.

Identifiants

DOI: 10.1016/j.apradiso.2020.109162 PMID: 32561130
pubmed: 32561130
pii: S0969-8043(20)30291-8
doi: 10.1016/j.apradiso.2020.109162
pii:
doi:

Substances chimiques

Gallium Radioisotopes 0
Heterocyclic Compounds, 1-Ring 0
Indium Radioisotopes 0
Oligopeptides 0
Radiopharmaceuticals 0
SP90 peptide 0
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 1HTE449DGZ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109162

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest No competing financial interests exist.

Auteurs

Wei-Lin Lo (WL)

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.

Chen-Hsien Liang (CH)

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.

Liang-Cheng Chen (LC)

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.

Shih-Ying Lee (SY)

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.

Sheng-Nan Lo (SN)

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.

Ming-Wei Chen (MW)

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.

Ruei-Min Lu (RM)

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.

I-Ju Liu (IJ)

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.

Han-Chung Wu (HC)

Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.

Chih-Hsien Chang (CH)

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan. Electronic address: chchang@iner.gov.tw.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Isotopes du gallium › Radio-isotopes du gallium › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes de l'indium › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Imagerie multimodale › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Imaging and biodistribution of radiolabeled...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Imaging and biodistribution of radiolabeled...