Capillary Density Measured by Optical Coherence Tomography Angiography in Glaucomatous Optic Disc Phenotypes.
Aged
Capillaries
/ diagnostic imaging
Case-Control Studies
Cross-Sectional Studies
Female
Fluorescein Angiography
Glaucoma, Open-Angle
/ diagnostic imaging
Gonioscopy
Humans
Intraocular Pressure
/ physiology
Male
Middle Aged
Nerve Fibers
/ pathology
Optic Disk
/ blood supply
Optic Nerve Diseases
/ diagnostic imaging
Phenotype
Retinal Ganglion Cells
/ pathology
Tomography, Optical Coherence
Tonometry, Ocular
Visual Fields
Journal
American journal of ophthalmology
ISSN: 1879-1891
Titre abrégé: Am J Ophthalmol
Pays: United States
ID NLM: 0370500
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
17
01
2020
revised:
23
04
2020
accepted:
10
06
2020
pubmed:
21
6
2020
medline:
22
12
2020
entrez:
21
6
2020
Statut:
ppublish
Résumé
To compare optical coherence tomography angiography (OCTA)-measured capillary density of the optic disc among 4 glaucomatous optic disc phenotypes. Cross-sectional study. Circumpapillary capillary density (cpCD) of 4 glaucomatous optic disc phenotypes in 193 eyes of 141 glaucoma patients and cpCD in 92 eyes of 55 healthy subjects from the Diagnostic Innovations in Glaucoma Study (DIGS) were compared. Areas under the receiver operating characteristic (AUROC) curves were used to evaluate diagnostic accuracy among groups after adjusting for confounders. Four glaucoma phenotypes were assessed: focal ischemic (n = 45), generalized cup enlargement (n = 60), myopic glaucoma (n = 38), and senile sclerotic (n = 50). Sex, mean ocular perfusion pressure, intraocular pressure, mean deviation, and the quality score did not differ among phenotypes. However, there were differences in age (P = .050), race (P = .039), axial length (P = .033), and retinal nerve fiber layer thickness (P < .001) among the groups. After adjusting for confounders, senile sclerotic discs had the lowest cpCD (37.1% [95% confidence interval, 35.3-38.8]), followed by focal ischemic (41.8% [40.0-43.6]), myopic glaucoma (42.1% [40-44.2]), and generalized cup enlargement (45.5% [44-47]) (P < .001) discs. The adjusted AUROC curves of cpCD for discriminating between healthy and glaucomatous eyes were highest in senile sclerotic eyes (0.928) and lowest in generalized cup enlargement eyes (0.704). OCTA-measured vessel density differs among optic disc phenotypes. Clinicians should be aware that the performance of OCTA for glaucoma diagnosis may be influenced by the optic disc phenotype.
Identifiants
pubmed: 32561168
pii: S0002-9394(20)30308-1
doi: 10.1016/j.ajo.2020.06.012
pmc: PMC7606542
mid: NIHMS1604701
pii:
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
261-270Subventions
Organisme : NEI NIH HHS
ID : P30 EY022589
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029058
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY027945
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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