The crosstalk between cellular reprogramming and senescence in aging and regeneration.

Cellular Reprogramming Cellular Senescence Rejuvenation
Aging Cellular plasticity Cellular reprogramming Cellular senescence Regeneration Rejuvenation

Journal

Experimental gerontology
ISSN: 1873-6815
Titre abrégé: Exp Gerontol
Pays: England
ID NLM: 0047061

Informations de publication

Date de publication:
09 2020
Historique:
received: 18 12 2019
revised: 17 05 2020
accepted: 10 06 2020
pubmed: 21 6 2020
medline: 28 4 2021
entrez: 21 6 2020
Statut: ppublish

Résumé

Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue regeneration and rejuvenation. Here we review recent studies on the interplay between cellular senescence and reprogramming. We discuss how both strategies could impact aging process and the possibility of combine them for more efficient regeneration and rejuvenation.

Identifiants

DOI: 10.1016/j.exger.2020.111005 PMID: 32561400
pubmed: 32561400
pii: S0531-5565(20)30353-3
doi: 10.1016/j.exger.2020.111005
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111005

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Aurélie Chiche (A)

Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France.

Cheng Chen (C)

Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France.

Han Li (H)

Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France. Electronic address: han.li@pasteur.fr.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › The crosstalk between cellular reprogramming...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › The crosstalk between cellular reprogramming...
questionsmedicales.fr › Thérapeutique › Rajeunissement › The crosstalk between cellular reprogramming...