Ontogeny of renin gene expression in the chicken, Gallus gallus.
Chicken embryo
Juxtaglomerular apparatus
Nephrogenesis
Renin gene expression
Renin ontogeny
Renin-angiotensin system
Journal
General and comparative endocrinology
ISSN: 1095-6840
Titre abrégé: Gen Comp Endocrinol
Pays: United States
ID NLM: 0370735
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
31
05
2019
revised:
02
06
2020
accepted:
06
06
2020
pubmed:
21
6
2020
medline:
4
2
2021
entrez:
21
6
2020
Statut:
ppublish
Résumé
Renin or a renin-like enzyme evolved in ancestral vertebrates and is conserved along the vertebrate phylogeny. The ontogenic development of renin, however, is not well understood in nonmammalian vertebrates. We aimed to determine the expression patterns and relative abundance of renin mRNA in pre- and postnatal chickens (Gallus gallus, White Leghorn breed). Embryonic day 13 (E13) embryos show renal tubules, undifferentiated mesenchymal structures, and a small number of developing glomeruli. Maturing glomeruli are seen in post-hatch day 4 (D4) and day 30 (D30) kidneys, indicating that nephrogenic activity still exists in kidneys of 4-week-old chickens. In E13 embryos, renin mRNA measured by quantitative polymerase chain reaction in the adrenal glands is equivalent to the expression in the kidneys, whereas in post-hatch D4 and D30 maturing chicks, renal renin expressions increased 2-fold and 11-fold, respectively. In contrast, relative renin expression in the adrenals became lower than in the kidneys. Furthermore, renin expression is clearly visible by in situ hybridization in the juxtaglomerular (JG) area in D4 and D30 chicks, but not in E13 embryos. The results suggest that in chickens, renin evolved in both renal and extrarenal organs at an early stage of ontogeny and, with maturation, became localized to the JG area. Clear JG structures are not morphologically detectable in E13 embryos, but are visible in 30-day-old chicks, supporting this concept.
Identifiants
pubmed: 32561435
pii: S0016-6480(20)30286-0
doi: 10.1016/j.ygcen.2020.113533
pmc: PMC7678913
mid: NIHMS1644960
pii:
doi:
Substances chimiques
RNA, Messenger
0
Renin
EC 3.4.23.15
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
113533Subventions
Organisme : NIDDK NIH HHS
ID : P50 DK096373
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116196
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116718
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148044
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that no conflict of interest exists.
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