Biomarkers of aging and lung function in the normative aging study.

Aged Aged, 80 and over Aging / genetics Biomarkers / analysis DNA, Mitochondrial / genetics Epigenesis, Genetic / physiology Female Forced Expiratory Volume / genetics Gene Dosage Humans Linear Models Lung / physiology Male Maximal Midexpiratory Flow Rate / genetics Middle Aged Models, Genetic Telomere Homeostasis / physiology Vital Capacity / genetics
DNA methylation biological clock pulmonary health

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
19 06 2020
Historique:
received: 20 02 2019
accepted: 20 05 2020
pubmed: 21 6 2020
medline: 9 3 2021
entrez: 21 6 2020
Statut: ppublish

Résumé

Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis in the Normative Aging Study using linear mixed-effect models. We generated GrimAgeAccel, PhenoAgeAccel, extrinsic and intrinsic epigenetic age acceleration using a publically available online calculator. We calculated Zhang's DNAmRiskScore based on 10 CpGs. We measured telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) using quantitative real-time polymerase chain reaction. A pulmonary function test was performed measuring forced expiratory volume in 1 second / forced vital capacity (FEV

Identifiants

DOI: 10.18632/aging.103363 PMID: 32561690 PMC: PMC7343502
pubmed: 32561690
pii: 103363
doi: 10.18632/aging.103363
pmc: PMC7343502
doi:

Substances chimiques

Biomarkers 0
DNA, Mitochondrial 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

11942-11966

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES015172
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025225
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES027747
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021733
Pays : United States

Références

Aging (Albany NY). 2018 Apr 18;10(4):573-591
pubmed: 29676998
Clin Epigenetics. 2016 Jun 03;8:64
pubmed: 27274774
Eur Respir J. 2018 Mar 1;51(3):
pubmed: 29348151
Environ Pollut. 2020 Mar;258:113690
pubmed: 31818625
Epidemiol Rev. 2013;35:112-31
pubmed: 23302541
Epigenetics. 2017 Feb;12(2):139-148
pubmed: 27982729
J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):640-9
pubmed: 24249734
Pediatr Pulmonol. 2019 Dec;54(12):2044-2052
pubmed: 31456360
Thorax. 2017 Jul;72(7):646-653
pubmed: 28100713
Am J Epidemiol. 1998 Jun 1;147(11):1011-8
pubmed: 9620044
Postgrad Med. 2017 Nov;129(8):902-906
pubmed: 28936887
Annu Rev Biochem. 1996;65:337-65
pubmed: 8811183
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Environ Health Perspect. 2017 Jan;125(1):76-81
pubmed: 27259001
Nat Rev Genet. 2018 Jun;19(6):371-384
pubmed: 29643443
Am J Respir Crit Care Med. 2012 Jun 15;185(12):1301-6
pubmed: 22561963
Mitochondrion. 2007 Dec;7(6):386-95
pubmed: 17981517
Front Public Health. 2017 Dec 11;5:335
pubmed: 29312916
Gerontologist. 1966 Dec;6(4):179-84
pubmed: 5342911
Aging (Albany NY). 2015 Sep;7(9):690-700
pubmed: 26411804
Gerontology. 2004 Jul-Aug;50(4):230-4
pubmed: 15258428
Int J Epidemiol. 2015 Aug;44(4):1388-96
pubmed: 25617346
Nucleic Acids Res. 2002 May 15;30(10):e47
pubmed: 12000852
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1561-1568
pubmed: 27856493
Aging (Albany NY). 2015 Dec;7(12):1198-211
pubmed: 26684672
BMC Genomics. 2017 Jan 3;18(1):4
pubmed: 28049437
Genes Brain Behav. 2019 Jun;18(5):e12565
pubmed: 30887649
Am Rev Respir Dis. 1987 Nov;136(5):1285-98
pubmed: 3674589
Chest. 1999 Jul;116(1):150-6
pubmed: 10424519
Environ Health Perspect. 2010 Nov;118(11):1564-70
pubmed: 21465749
PLoS One. 2015 Sep 22;10(9):e0138716
pubmed: 26394041
Nat Rev Genet. 2005 Aug;6(8):611-22
pubmed: 16136653
Age (Dordr). 2011 Sep;33(3):385-92
pubmed: 20878489
Eur Respir J. 2005 Aug;26(2):319-38
pubmed: 16055882
Clin Epigenetics. 2017 Dec 21;9:132
pubmed: 29299071
Eur Respir J. 2010 Nov;36(5):1002-6
pubmed: 20562119
Epigenetics. 2012 Mar;7(3):261-9
pubmed: 22430802
Clin Epigenetics. 2019 Jan 24;11(1):15
pubmed: 30678737
Nat Rev Mol Cell Biol. 2007 Sep;8(9):692-702
pubmed: 17700626
Aging (Albany NY). 2017 Feb 14;9(2):419-446
pubmed: 28198702
Thorax. 2003 May;58(5):388-93
pubmed: 12728157
Epigenetics. 2018;13(10-11):1039-1055
pubmed: 30343628
Eur Respir J. 2004 Sep;24(3):397-405
pubmed: 15358698
Aging (Albany NY). 2019 Jan 21;11(2):303-327
pubmed: 30669119
Nat Commun. 2017 Mar 17;8:14617
pubmed: 28303888
Mitochondrion. 2009 Jul;9(4):242-6
pubmed: 19272467
Circulation. 2016 Jan 26;133(4):378-87
pubmed: 26660284
Aging (Albany NY). 2015 Dec;7(12):1130-42
pubmed: 26655927
Mitochondrion. 2011 Jan;11(1):207-13
pubmed: 20933104
Genome Biol. 2013;14(10):R115
pubmed: 24138928

Auteurs

Cuicui Wang (C)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Allan Just (A)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Jonathan Heiss (J)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Brent A Coull (BA)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Lifang Hou (L)

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Yinan Zheng (Y)

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

David Sparrow (D)

VA Normative Aging Study, VA Boston Healthcare System, Boston, MA 02130, USA.
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

Pantel S Vokonas (PS)

VA Normative Aging Study, VA Boston Healthcare System, Boston, MA 02130, USA.
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

Andrea Baccarelli (A)

Department of Epidemiology and Environmental Health Sciences, Columbia University, New York, NY 10027, USA.

Joel Schwartz (J)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Ventilation pulmonaire › Volume expiratoire maximal par seconde › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Dosage génique › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Appareil respiratoire › Poumon › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Ventilation pulmonaire › Débits expiratoires forcés › Débit expiratoire maximal médian › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles génétiques › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Homéostasie des télomères › Biomarkers of aging and lung function in the...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Capacité pulmonaire totale › Capacité vitale › Biomarkers of aging and lung function in the...